Tea catechins as cancer specific proliferation inhibitors
AssigneePurdue Research Foundation
InventorsDorothy M. Morre, D. James Morre
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Abstract
The invention described herein encompasses a methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds.
Claims75
A method for treating cancer in a mammal which comprises administering to a mammal in need of cancer treatment, wherein the cancer is a type having cancer cells which express tNOX, a therapeutically effective amount of a composition comprising tea catechins.
A method for treating a solid tumor in a mammal which comprises administering to a mammal with a solid tumor, wherein the solid tumor comprises cancer cells which express tNOX, a therapeutically effective amount of a composition comprising tea catechins.
A method for treating metastases in a human which comprises administering to a human having a primary cancer, wherein the cancer is a type having cancer cells which express tNOX, a therapeutically effective amount of a composition comprising tea catechins.
A method for treating cancer in a mammal which comprises administering to a mammal in need of therapy a therapeutically effective amount of a catechin composition, or a pharmaceutically acceptable salt thereof, in combination with an effective amount of at least one other chemotherapeutic agent.
A composition for use in a mammal which comprises a therapeutically effective amount of a composition comprising tea catechins.
Dependencies are inferred from the claim text.