Compositions, implants, methods, and kits for closure of lumen openings, repair of ruptured tissue, and for bulking of tissue
OwnerJohn F. Wironen, Russell S. Dondainventors
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Abstract
Disclosed and claimed are compositions, devices, methods and kits that are useful in occluding lumens or bulking-up regions of tissues or organs in a living mammal. The invention pertains to compositions, containing specific bioactive components in combination with carriers, and tissue based implants, wherein the bioactive components promote responsive body processes that contribute to the formation of the occlusion or bulked-up region or repair of damaged tissue. Also disclosed is an expandable collagen sponge for implantation into lumens, voids, and cavities.
Claims57
A method of administering a closure-forming or bulking up composition in a living mammal, comprising
- a. mixing together, to form a composition, at least one type of water-insoluble particle and a carrier;
- and
- b. applying the composition to at least one specific area of a lumen or other body region in need of closure;
- whereby applying the composition results in closure or bulking up of the at least one specific area.
A method of administering a closure-forming or bulking up composition in a living mammal, comprising
- a. mixing together, to form a composition, at least one type of water-insoluble particle that promotes responsive body processes and a carrier;
- and
- b. applying the composition to at least one specific area of a lumen or other body region in need of closure;
- whereby applying the composition results in closure or bulking up of the at least one specific area.
A method of administering a closure-forming or bulking up composition in a living mammal, comprising
- a. obtaining at least one type of water-insoluble particle that promotes responsive body processes, from the group consisting fine particles of bone;
- fine particles of hydroxyapatite, in the 1 to 70 micrometers particle size range;
- non-osteoinductive demineralized bone matrix, preferably in the 125-250 micrometer particle size range;
- collagen shards, preferably in the 125-250 micrometer particle size range;
- insoluble salts, and talc;
- b. mixing together, to form a composition, said at least one type of water-insoluble particle and a carrier;
- and
- c. applying the composition to at least one specific area of a lumen or other body region in need of closure, or tissue or organ in need of bulking up;
- whereby applying the composition results in closure or bulking up of the at least one specific area.
An implantable composition for administration to a lumen of a living mammal, to close the lumen, comprising:
- a. water-insoluble particles, and
- b. a carrier compound, such that when combined in a liquid, the water-insoluble particles are suspended in a solution.
An implantable composition for administration to a lumen of a living mammal, to close the lumen, comprising:
- a. water-insoluble particles that promote responsive body processes, and
- b. a carrier compound, such that when combined in a liquid, the water-insoluble particles are suspended in a solution.
An implantable composition for administration to a lumen of a living mammal, to close the lumen, comprising:
- a. water-insoluble particles that promote responsive body processes, and
- b. a carrier compound, such that when combined in a liquid, the water-insoluble particles are suspended in a solution,
- wherein said carrier compound is thermoplastic gelatin and said solution is flowable at a temperature above the body temperature of a subject living mammal, and is not flowable at the said body temperature.
An implantable composition for administration to a tissue or organ of a living mammal, to add bulk to the tissue or organ, comprising water-insoluble particles in a carrier compound, such that when combined in a liquid, the water-insoluble particles are suspended in a solution.
An implantable composition for administration to a tissue or organ of a living mammal, to add bulk to the tissue or organ, comprising:
- a. water-insoluble particles that promote responsive body processes, and
- b. a carrier compound, such that when combined in a liquid, the water-insoluble particles are suspended in a solution.
An implantable composition for administration to a tissue or organ of a living mammal, to add bulk to the tissue or organ, comprising:
- a. water-insoluble particles that promote responsive body processes, and
- b. a carrier compound, such that when combined in a liquid, the water-insoluble particles are suspended in a solution,
- wherein said carrier compound is thermoplastic gelatin and said solution is flowable at a temperature above the body temperature of a subject living mammal, and is not flowable at the said body temperature.
A method of promoting the formation of an occlusion in a lumen, or a bulked-up region in a tissue or organ, comprising the steps of:
- a. preparing a composition comprising water insoluble particles, said particles promoting formation of an adhesion, and
- b. injecting a quantity of said composition into a body area of a living mammal, such that adhesion formation is promoted in the area of the injecting.
A method of promoting the lessening or cessation of menorrhea, comprising the steps of:
- a. preparing a composition comprising water insoluble particles, said particles promoting an inflammatory response, and
- b. applying a quantity of said composition into the uterus of a living female mammal in need of said lessening or cessation of menorrhea,
- whereby said inflammatory response results in said lessening or cessation of menorrhea.
A kit for lumen-closing or a tissue-bulking implant for a living mammal, comprising:
- a. an implantable composition comprising water-insoluble particles that promote one or more of cellular inflammation, infiltration, or adhesion, and a carrier to form a paste or suspension;
- and
- b. instructions for delivering said implantable composition to a lumen, tissue or organ in need of occlusion or bulking,
- wherein upon said delivering, an occlusion forms in the lumen, or a bulked up area forms in the tissue or organ of the living mammal.
A method for closure of a lumen, or bulking up of a tissue or organ in a living mammal, comprising:
- a. obtaining a kit comprising an implantable composition comprising water-insoluble particles that promote one or more of cellular inflammation, infiltration, or adhesion, and a carrier to form a paste or suspension;
- and
- b. administering said implantable composition to a lumen in need of closure, or to a tissue or organ in need of bulking up.
A method of promoting the lessening or cessation of menorrhea, comprising the steps of:
- a) constructing an expandable sponge;
- and
- b) implanting said sponge into the uterine cavity of a patient.
An expandable tissue based sponge for implantation into a lumen.
A method of repairing a ruptured intervertebral disc comprising administering a closure-forming composition to an annulus fibrosus.
A method of blocking or filling at least one lumen comprising implanting an expandable sponge or hydrogel into said at least one lumen.
Dependencies are inferred from the claim text.