Topical drug preparations

A method for the treatment of a condition in animals for a sustained period of time, which comprises:

• topically applying a therapeutically effective dose of a gelled composition comprising a polymer matrix which is suspended in a liquid medium;
• wherein the polymer matrix contains a negatively charged polymer blended with a nonionic polymer.

A process for the use of a composition as a medical device, for drug delivery, the application of a diagnostic agent, or the prevention of post operative adhesions, said process comprises topically administering to a mammal an aqueous based gelled composition containing a polymer matrix composed of negatively charged polymers blended with nonionic polymers.

An antiarthritic gelled composition, which comprises:

• therapeutically effective amounts of an active NSAID drug dispersed within a matrix containing a negative charged polymer having a mean average molecular weight between about 650,000 and 800,000 blended with a nonionic polymer, wherein the molar ratio of the charged polymer to the nonionic polymer is 1:0.5 to 4 and the negative charged polymer is present in amounts of about 2.0% to about 3.0% by weight.

A method for treating an arthritic condition, which comprises:

• topically administering to a mammal an aqueous based gelled composition containing therapeutically effective amounts of an NSAID drug dispersed within a polymer matrix composed of negatively charged polymers blended with nonionic polymers, wherein the molar ratio of the negatively charged polymer to nonionic polymer is 1:0.5 to 4.