Topical gel delivery system
AssigneeDow Pharmaceutical Sciences, Inc.
InventorsGordon J. Dow, Robert W. Lathrop, Debra A. Dow
Life of this patent
Estimating the term…
Abstract
A composition is provided that has a viscosity of less than about 15,000 cP and a pH of about 3.0 to 9.0 for treating a skin disorder in a human subject. The composition is a lotion that consists essentially of (a) a therapeutically-effective amount of at least one compound useful for treating such disorder, (b) a pharmaceutically-acceptable, lightly cross-linked polyacrylic acid polymer compatible with the compound, (c) a pharmaceutically acceptable base to adjust pH, (d) up to about 25% ww of at least one water miscible solvent, (e) optionally a preservative, (f) water, and (g) an oil phase component and suitable surfactant. The composition is useful for treating an inflammatory skin disorder, acne, or rosacea.
Claims56
A composition having a pH of about 3 to about 9 and a viscosity of less than about 15,000 cP for treating a skin disorder in a human subject, which composition consists essentially of
- (a) a therapeutically-effective amount of at least one compound useful for treating such disorder,
- (b) a pharmaceutically-acceptable, lightly cross-linked polyacrylic acid polymer compatible with the compound,
- (c) a pharmaceutically-acceptable base to adjust pH,
- (d) optionally a water miscible solvent,
- (e) optionally a preservative,
- (f) optionally at least one surfactant alone or in combination with an oil phase, and
- (g) water.
A method for treating a skin disorder in a human subject, which method comprises topically administering a composition having a pH of about 3 to about 9 and a viscosity of less than about 15,000 cP to an affected area of the subject's skin having such disorder in an amount and for a period of time sufficient to improve the skin disorder, wherein the composition consists essentially of
- (a) a therapeutically-effective amount of at least one compound useful for treating such disorder,
- (b) a pharmaceutically-acceptable lightly cross-linked polyacrylic acid polymer compatible with the pharmaceutical active material,
- (c) a pharmaceutically-acceptable base to adjust pH
- (d) optionally a water miscible solvent,
- (e) optionally a preservative,
- (f) optionally an oil phase in combination with a surfactant, and
- (g) water.
A method of preparing a composition having a viscosity of less than about 15,000 cP and a pH of about 3 to 9 useful for treating a skin disorder in a human subject, which method comprises
- (a) combining water with a therapeutically-effective amount of at least one compound —useful for treating such disorder and a pharmaceutically-acceptable, lightly cross-linked polyacrylic acid polymer compatible with the compound,
- (b) adjusting the pH to about 3 to 9, and
- (c) optionally combining a water-miscible solvent, a preservative, and at least one surfactant alone or in combination with an oil phase component to form the composition.
Dependencies are inferred from the claim text.