Pharmaceutical compositions comprising amlodipine maleate
AssigneeSynthon BV
InventorsJacobus M. Lemmens, Frans van Dalen, Arlette Vanderheijden
Life of this patent
Estimating the term…
Abstract
An amlodipine maleate pharmaceutical composition is provided with good stability when formulated with a pH within the range of 5.5 to 7, when measured as a 20 wt % aqueous slurry. The stability can also be aided by making the pharmaceutical composition from amlodipine maleate particles having an average particle size of greater than 20 microns, preferably greater than 100 microns.
Claims27
A pharmaceutical composition comprising an effective amount of amlodipine maleate and at least one pharmaceutically acceptable excipient wherein said composition has a pH within the range of 5.5-7.0.
A process, which comprises:
- mixing amlodipine maleate and at least one pharmaceutically acceptable excipient to form a mixture having a pH of 5.5-7.0.
A process, which comprises:
- mixing solid particles of amlodipine maleate, having an average particle size of at least 20 microns, with a pharmaceutically acceptable excipient to form a mixture.
Dependencies are inferred from the claim text.