Pain treatment by peripheral administration of a neurotoxin
AssigneeAllergan Sales, Inc.
InventorsKei Roger Aoki, Minglei Cui, Stephen W. Jenkins
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Abstract
Methods for treating a non-spasm caused pain by peripheral administration to a patient of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin.
Claims27
A method for treating pain, the method comprising the step of peripheral administration of a neurotoxin to a mammal, wherein the pain treated is not associated with a muscle spasm.
A method for alleviating pain, the method comprising the step of peripheral administration of a botulinum toxin to a human patient, thereby alleviating pain, wherein the pain is not associated with a muscle disorder.
A method for treating a pain, the method comprising the step of peripheral administration of a neurotoxin to a mammal, wherein the neurotoxin is a polypeptide comprising:
- a) a first amino acid sequence region comprising a wild type neuronal binding moiety, substantially completely derived from a neurotoxin selected from a group consisting botulinum toxin types A, B, C1, D, E, F, G and mixtures thereof;
- b) a second amino acid sequence region effective to translocate the polypeptide or a part thereof across an endosome membrane;
- and
- c) a third amino acid sequence region having therapeutic activity when released into a cytoplasm of a target cell,
- wherein the pain is not associated with a muscle spasm.
A method for improving patient function, the method comprising the step of peripheral administration of a botulinum toxin to a patient experiencing a non-muscle disorder related pain, thereby improving patient function as determined by improvement in one or more of the factors of reduced pain, reduced time spent in bed, improve hearing, increased ambulation, healthier attitude and a more varied lifestyle.
A method for treating post-operative pain, the method comprising the step of peripheral administration of an effective amount of a botulinum toxin before, during or immediately after a surgical procedure, thereby alleviating a post-operative pain, wherein the surgical procedure is not carried out to treat a muscle spasm.
23 A method for treating a visceral pain the method comprising the step of non-systemic, local administration of an effective amount of a botulinum toxin, thereby alleviating a visceral pain.
A method for treating pain, the method comprising the step of peripheral dministration of a neurotoxin to a mammal, wherein the pain is not substantially due to a muscle spasm.
Dependencies are inferred from the claim text.