Methods and compositions useful for stimulating an immune response
AssigneeChemoCentryx, Inc.
InventorsThomas J. Schall, Mark E.T. Penfold
Life of this patent
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Abstract
The invention provides compositions containing modified cytomegalovirus, and methods of using the compositions. In various embodiments, the modifications include adding a heterologous sequence encoding a non-viral chemokine element and/or immunogenic polypeptide, and/or disabling a viral dissemination gene.
Claims78
A recombinant cytomegalovirus (CMV), comprising a cytomegalovirus (CMV) genome which comprises a first heterologous nucleotide sequence encoding a heterologous chemokine element, and (ii) a second heterologous nucleotide sequence encoding an immunogenic polypeptide.
A recombinant cytomegalovirus (CMV) comprising a cytomegalovirus (CMV) genome that comprises a heterologous nucleotide sequence encoding a heterologous chemokine receptor or ligand.
A recombinant CMV comprising a cytomegalovirus (CMV) genome that comprises a heterologous nucleotide sequence encoding an immunogenic polypeptide.
A method for inducing an immune response in a host, the method comprising administering a composition to a host, wherein the composition comprises a recombinant cytomegalovirus (CMV) with a genome that contains (i) a first heterologous nucleotide sequence encoding a heterologous chemokine element, and (ii) a second heterologous nucleotide sequence encoding an immunogenic polypeptide.
A therapeutic or prophylactic treatment method, the method comprising administering a composition to an animal, wherein
- (a) the composition comprises an attenuated recombinant cytomegalovirus (CMV) with a genome that contains (i) a first nucleotide sequence encoding a chemokine receptor or chemokine that is endogenous to the animal, and (ii) a second nucleotide sequence encoding an immunogenic polypeptide;
- and
- (b) the immunogenic polypeptide comprises an antigen correlated with a disease or infection which the animal has or is susceptible to obtaining;
- and whereby the administered composition induces an immune response in the animal.
A method of preparing a recombinant CMV, comprising inserting into a CMV genome (i) a first heterologous nucleotide sequence encoding a heterologous chemokine element, and (ii) a second heterologous nucleotide sequence encoding an immunogenic polypeptide.
Dependencies are inferred from the claim text.