Monoclonal antibodies to TGF-BETA
OwnerJames R. Dasch, Doran R. Pace III +1inventors
InventorsJames R. Dasch, Doran R. Pace III, Wendy O. Waegell
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Abstract
Monoclonal antibodies to transforming growth factor beta (TGF-B) are prepared from hybrid cell lines by immunizing with TGF-B2. The antibodies may be of any isotype and may be of any mammalian origin such as murine or human origin. Therapeutic applications utilizing the TGF-B monoclonal antibody are also disclosed.
Claims15
A monoclonal antibody reactive with transforming growth factor-beta.
The monoclonal antibody 1D11.16.
A method for preventing acute or chronic fibrosis, comprising administering a therapeutically effective amount of a monoclonal antibody reactive with TGF-B.
The method of claim 12 wherein the monoclonal antibody reactive with TGF-B binds an epitope on TGF-B, thereby blocking the binding of TGF-B to TGF-B cellular receptors.
A method for neutralizing the inhibitory effects of TGF-B, which method comprises administering a therapeutically effective amount of a monoclonal antibody reactive with TGF-B.
A method for inducing tumor regression in a mammal having tumor cells which produce TGF-B, which method comprises:
- administering an amount of a monoclonal antibody reactive with TGF-B sufficient to reduce the immunosuppressive effects of TGF-B produced by said tumor cells.
Dependencies are inferred from the claim text.