Mitogenic oxygenase regulators
AssigneeEmory University
InventorsJ. David Lambeth, Guangjie Cheng
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Abstract
The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.
Claims22
An isolated protein capable of stimulating superoxide production, wherein the isolated protein comprises the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4, or a fragment thereof, or a conservative substitution thereof.
An isolated protein capable of stimulating superoxide production, wherein the isolated protein comprises the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4, a deletion thereof or an addition thereto of no more than about 20% of the amino acid sequence, or a conservative substitution thereof, wherein the conservative substitution comprises substitution of:
- a) alanine, serine, or threonine for each other;
- b) aspartic acid or glutamic acid for each other;
- c) asparagine or glutamine for each other;
- d) arginine or lysine for each other;
- e) isoleucine, leucine, methionine, or valine for each other;
- and
- f) phenylalanine, tyrosine, or tryptophan for each other.
An isolated nucleotide sequence comprising the sequence of SEQ ID NO:5, a conservative substitution or fragment thereof.
Dependencies are inferred from the claim text.