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OwnerBrian Seed, Charles Romeo +1inventors
InventorsBrian Seed, Charles Romeo, Waldemar Kolanus
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Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. The chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent, and (b) an intracellular portion of a protein-tyrosine kinase which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.
A method of directing a cellular immune response in a mammal, said method comprising administering to said mammal an effective amount of therapeutic cells, each of said therapeutic cells expressing a membrane-bound, proteinaceous chimeric receptor, comprising (a) an intracellular portion of a protein-tyrosine kinase which is capable of signalling said therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent and (b) an extracellular portion which is capable of specifically recognizing and binding said target cell or said target infective agent, whereby each of said therapeutic cells is capable of specifically recognizing and destroying said target cell or target infective agent.
A cell which expresses a membrane-bound, proteinaceous chimeric receptor, comprising (a) an intracellular portion of a protein-tyrosine kinase which is capable of signalling said therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent and (b) an extracellular portion which is capable of specifically recognizing and binding said target cell or said target infective agent, whereby each of said therapeutic cells is capable of specifically recognizing and destroying said target cell or target infective agent.
A cell which expresses a membrane-bound, proteinaceous chimeric receptor comprising (a) an intracellular portion of a protein-tyrosine kinase and (b) an extracellular portion which is capable of specifically recognizing and binding a target cell or target infective agent.
DNA encoding a chimeric receptor encoding a membrane-bound, proteinaceous chimeric receptor, comprising (a) an intracellular portion of a protein-tyrosine kinase which is capable of signalling said therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent and (b) an extracellular portion which is capable of specifically recognizing and binding said target cell or said target infective agent, whereby each of said therapeutic cells is capable of specifically recognizing and destroying said target cell or target infective agent.
DNA encoding a membrane-bound, proteinaceous chimeric receptor comprising (a) an intracellular portion of a protein-tyrosine kinase and (b) an extracellular portion which is capable of specifically recognizing and binding a target cell or target infective agent.
Dependencies are inferred from the claim text.