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US 2002/0176842 A1Published application
Extended release of active ingredients
OwnerLyn Hughes, Simon Andrew Bellamy +1inventors
InventorsLyn Hughes, Simon Andrew Bellamy, Christina Hann
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Abstract
A dosage form is described that gives an extended release of active ingredients using unloaded ion exchange resins, that does not require the manufacture of a resinate.
Claims5
A dosage form comprising:
- a. an ionizable active ingredient;
- b. an unloaded ion exchange resin.
A dosage form comprising:
- a an ionizable active ingredient;
- b. an unloaded ion exchange resin;
- further provided that the release rate and absorption rate of said ionizable active ingredient from said dosage form into a release medium can be modified by changing the variables, selected from the group consisting of, degree of cross-linking of the unloaded ion exchange resin, the particle size of the unloaded ion exchange resin, the pK of the functional groups of the unloaded resin, the solubility of the ionizable active ingredient in the release medium, the ionic strength and pH of the release medium, the pK of the ionizable active ingredient, the molecular weight of the ionizable active ingredient, temperature, and coating the unloaded ion exchange resin with a permeable membrane.
A dosage form comprising:
- a. an ionizable active ingredient;
- b. an unloaded ion exchange resin;
- further provided that the site at which release and absorption take place can be modified by coating the unloaded resin and/or active ingredient with a non-permeable membrane that is dissolved only at the site where absorption and release are desired.
Dependencies are inferred from the claim text.