# US 2002/0176822 A1 · MR signal-emitting coatings

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- Number: US 2002/0176822 A1
- Document ID: US20020176822A1
- Status: Published application
- Kind: A1
- Application number: 10/096,368
- Filed: 2002-03-12
- Published: 2002-11-28
- Earliest claimed: 1998-05-26
- Assignees: Wisconsin Alumni Research Foundation
- Inventors: Richard Frayne; Charles M. Strother; Orhan Unal; Zhihao Yang; Abukar Wehelie; Hyuk Yu
- Web page: https://patentgrep.com/patent/US20020176822A1

## CPC

- A61K 49/12: Macromolecular compounds
- A61K 49/085: {conjugated systems}
- A61K 49/18: characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61L 29/18: Materials at least partially X-ray or laser opaque
- A61L 31/18: Materials at least partially X-ray or laser opaque
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer complex that facilitates diagnostic and therapeutic techniques by readily visualizing medical devices coated with the complex.

## Claims

### Claim 1

A magnetic resonance imaging system, comprising:
a magnetic resonance device for generating a magnetic resonance image of a target object in an imaging region; and
an instrument for use with the target object in the imaging region, said instrument including a body sized for use in the target object and a polymeric-paramagnetic ion complex coating thereon in which said complex is represented by formula (I):
P-X-L-Mn+ (I)
wherein P is a polymer, X is a surface functional group, L is a chelate, M is a paramagnetic ion and n is an integer that is 2 or greater.

### Claim 2 (depends on 1)

The system of claim 1, wherein P is selected from the group consisting of polyethylene, polypropylene, polyesters, polyamides, polyfluoroethylene and polyurethanes.

### Claim 3 (depends on 1)

The system of claim 1, wherein X is an amino group or a carboxyl group.

### Claim 4 (depends on 1)

The system of claim 1, wherein M is a lanthanide or a transition metal which is iron, manganese, chromium, cobalt or nickel.

### Claim 5

A coating for visualizing medical devices in magnetic resonance imaging, comprising a complex of formula (I):
P-X-L-Mn+ (I)
wherein P is a polymer, X is a surface functional group, L is a chelate, M is a paramagnetic ion and n is an integer that is 2 or greater.

### Claim 6 (depends on 5)

The coating of claim 5, wherein P is selected from the group consisting of polyethylene, polypropylene, polyesters, polyamides, polyfluoroethylene and polyurethanes.

### Claim 7 (depends on 5)

The coating of claim 5, wherein X is an amino group or a carboxyl group.

### Claim 8 (depends on 5)

The coating of claim 5, wherein M is a lanthanide or is a transition metal which is iron, manganese, chromium, cobalt or nickel.

### Claim 9

A coating for visualizing medical devices in magnetic resonance imaging, comprising a complex of formula (II):
P-X-J-L-Mn+ (II)
wherein P is a polymer, X is a surface functional group, L is a chelate, M is a paramagnetic ion, n is an integer that is 2 or greater and J is the linker or spacer molecule.

### Claim 10 (depends on 9)

The coating of claim 9, wherein P is selected from the group consisting of polyethylene, polypropylene, polyesters, polyamides, polyfluoroethylene and polyurethanes.

### Claim 11 (depends on 9)

The coating of claim 9, wherein X is an amino group or a carboxyl group.

### Claim 12 (depends on 9)

The coating of claim 9, wherein M is a lanthanide or is a transition metal which is iron, manganese, chromium, cobalt or nickel.

### Claim 13 (depends on 9)

The coating of claim 9, wherein J is a lactam.

### Claim 14

A method for visualizing medical devices in magnetic resonance imaging, comprising:
(a) coating the medical device with a polymeric-paramagnetic complex of formula (I):
P-X-L-Mn+ (I)
wherein P is a polymer, X is a surface functional group, L is a chelate, M is a paramagnetic ion and n is an integer that is 2 or greater.
(b) positioning the device within a target object; and
(c) imaging the target object and coated device.

### Claim 15 (depends on 14)

The method of claim 14, wherein P is selected from the group consisting of polyethylene, polypropylene, polyesters, polyamides, polyfluoroethylene and polyurethanes.

### Claim 16 (depends on 14)

The method of claim 14, wherein X is an amino group or a carboxyl group.

### Claim 17 (depends on 14)

The method of claim 14, wherein M is a lanthanide or is a transition metal which is iron, manganese, chromium, cobalt or nickel.

### Claim 18

An magnetic resonance (MR)-emitting coating, comprising a paramagnetic ion-containing polymer.

### Claim 19

A method of visualizing medical devices in magnetic resonance imaging, comprising coating the devices with a paramagnetic ion-containing polymer.