Microfluidic substrate assembly and method for making same
AssigneeProtasis Corporation
InventorsDavid Strand, Joseph Antocci, Peter Myers, David Barrow, Joseph Cefai, Tim Myers
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Abstract
A novel microfluidic substrate assembly and method for making same are disclosed. The substrate assembly comprises a multi-layer laminated substrate defining at least one fluid inlet port and at least one microscale fluid flow channel within the multi-layer substrate in fluid communication with the inlet port for transport of fluid. The substrate assembly may optionally comprise additional components and elements located within the substrate assembly or attached to the substrate assembly.
Claims35
A microfluidic substrate assembly comprising:
- a multi-layer laminated substrate defining at least one fluid inlet port and at least one microscale fluid flow channel within the multi-layer substrate in fluid communication with the inlet port for transport of fluid;
- and
- at least one operative component mounted aboard the multi-layer laminated substrate in communication with the microscale fluid flow channel.
A microfluidic substrate assembly comprising a generally planar multi-layer laminated substrate defining
- at least one fluid inlet port and at least one microscale fluid flow channel at each of more than one level within the multi-layer laminated substrate for transport of fluid, and
- at least one microchannel via extending between levels within the multi-layer laminated substrate for fluid communication between microscale fluid flow channels of different levels.
A microfluidic substrate assembly comprising a multi-layer laminated substrate defining at least one fluid inlet port and at least one microscale fluid flow channel in fluid communication with the inlet port for transport of fluid, wherein at least one layer of the multi-layer laminated substrate is formed of plastic and the substrate assembly is operative and fluid tight at fluid pressure in the microscale fluid flow channel in excess of about 100 psi.
17 The microfluidic substrate assembly of claim 15 in which the multi-layer laminated substrate further comprises rigid plates sandwiching the plastic layer between them.
The microfluidic substrate assembly of claim 17 in which multiple layers of the multi-layer laminated substrate are formed of plastic and are welded one to another, the rigid plates sandwiching the multiple plastic layer between them.
A microfluidic substrate assembly comprising a multi-layer laminated substrate defining at least one fluid inlet port and at least one microscale fluid flow channel within the multi-layer substrate in fluid communication with the inlet port for transport of fluid, in which at least one layer of the multi-layer laminated substrate is formed of PEEK.
A microfluidic substrate assembly comprising a multi-layer laminated substrate defining at least one fluid inlet port and at least one microscale fluid flow channel within the multi-layer substrate in fluid communication with the inlet port for transport of fluid, wherein at least first and second layers of the multi-layer laminated substrate are selectively welded to each other to form a fluid-tight seal at least along a channel within the multi-layer laminated substrate.
A method of producing a multi-layer laminated substrate, comprising the steps of:
- forming a surface-to-surface interface by aligning a surface of a first substrate component against a surface of a second substrate component to form a substrate subassembly having an internal fluid channel at the interface;
- and
- exposing the sub-assembly to radiation to heat only one or more selected portions of the interface to a temperature sufficient to weld the substrate components together, to form a fluid-tight seal between the substrate components at the interface along the fluid channel.
Dependencies are inferred from the claim text.