Reduced fluence rate PDT
AssigneeQLT Inc.
InventorH. Andrew Strong
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Abstract
The invention relates to the use of reduced fluence rate PDT to treat neovasculature, particularly choroidal neovasculature (CNV). Reduced fluence rate PDT decreases the likelihood of molecular oxygen being the limiting factor in the photodynamic reaction so that the concentration of either photons (light intensity) or photosensitizer in the target tissue controls the photodynamic reaction.
Claims20
A method for treating choroidal neovasculature using photodynamic therapy (PDT), comprising administering a photosensitizer (PS) to a subject afflicted with said neovasculature, and irradiating the PS with electromagnetic radiation containing a wavelength absorbed by said PS at a reduced fluence rate which does not deplete molecular oxygen levels in said neovasculature.
A method of treating choroidal neovasculature, comprising irradiating a subject afflicted with said neovasculature, and to whom a photosensitizer (PS) has been administered, with electromagnetic radiation containing a wavelength absorbed by said PS at a reduced fluence rate which permits the continued production of singlet oxygen.
A method of preventing depletion of molecular oxygen in neovasculature during photodynamic therapy (PDT) comprising irradiation with photosensitizer activating radiation at a reduced fluence rate.
Dependencies are inferred from the claim text.