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AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsAdolf Pfefferbaum, Elfar Adalsteinsson, Daniel Mark Spielman, Edith V. Sullivan
Estimating the term…
A non-invasive longitudinal method that is sensitive and objective for quantifying progressive loss of neurons in normal aging brains and brains that suffer from a neurodegenerative disease is provided. The method also provides clinicians, patients and drug companies with a method for evaluating the efficacy of various treatments and interventions by assessing a change in brain integrity. The method determines and localizes a change in brain integrity in a compartment of a brain from at least structural images and metabolite brain images, which are acquired for at least two time instances. The time period between two time instances is dependent on the disease pathology and disease progression and could, for instance, be at least 3 months between time instances as well as at least 6 or 12 months between time instances.
A non-invasive method to determine and localize a change in brain integrity in a compartment of a brain, comprising the steps of:
A non-invasive method to determine and localize a change in N-acetyl aspartate in a compartment of a brain, comprising the steps of:
A non-invasive method of assessing the efficacy of a treatment over a course of said treatment, wherein said treatment comprises at least two interventions at different time instances, by determining and localizing a change in brain integrity in a compartment of a brain, comprising the steps of:
Dependencies are inferred from the claim text.