Process for preparing a deuterated or tritiated compound
AssigneeThe Regents of the University of California
InventorsRobert C. Bergman, Steven R. Klei
Life of this patent
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Abstract
A process for labeling organic compounds with deuterium and tritium is described using specific catalysts.
Claims27
A method of preparing a deuterium labeled or tritium labeled compound comprising contacting an organic substrate with a catalyst having the at least one of the following structures:
- 6
- where M is selected from the group consisting of Co, Rh or Ir;
- A1 and A2 each independently represent ligands that are a 6 electron donor;
- L1 and L2 each independently represent ligands that are a 2 electron donor;
- X1, X2, X3, X4 and X5 each independently represent ligands that are a two electron donor;
- Y is an anion capable of creating a charge neutral complex, and contacting the organic substrate and said catalyst with a source of deuterium or tritium and heating the combination at a temperature of from 75-200° C.
A method of preparing a deuterium labeled or tritium labeled compound comprising contacting an organic substrate with a catalyst having at least one of the following structures:
- 7
- where M is selected from the group consisting of Fe, Ru and Os;
- A3 and A4 each independently represent ligands that are a 6 electron donor;
- L3 and L4 each independently represent ligands that are a 2 electron donor;
- X8, X9, X10, and X11 each independently represent ligands that are a two electron donor;
- and contacting the organic substrate and said catalyst with a source of deuterium or tritium and heating the combination at a temperature of from 75-200° C.
A method of preparing a deuterium labeled or tritium labeled compound comprising contacting an organic substrate with a catalyst having at least one of the following structures:
- 8
- where M is selected from the group consisting of Ni, Pd and Pt;
- A5 and A6 each independently represent ligands that are a 6 electron donor;
- L5 and L4 each independently represent ligands that are a 2 electron donor;
- X12 represents ligands that are a two electron donors;
- Y is an anion capable of creating a charge neutral complex,
- and contacting the organic substrate and said catalyst with a source of deuterium or tritium and heating the combination at a temperature of from 75-200° C.
Dependencies are inferred from the claim text.