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US 2002/0173661 A1Published application
Tri-aryl-substituted-ethane PDE4 inhibitors
AssigneeMerck Frosst Canada, Inc.
InventorsRichard Freisen, Yves Ducharme, Bernard Cote, Marc Blouin, Evelyn Martins, Daniel Guay, Pierre Hamel, Mario Girard, Richard Frenette, Sebastien Laliberte
Life of this patent
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Abstract
Novel ethanes substituted with i) a phenyl, ii) a thiazole, and iii) a pyridyl moiety are PDE4 inhibitors.
Claims19
A compound represented by Formula (I):
- 45
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is C1-6alkyl or C3-6cycloalkyl, optionally substituted with 1-4 independent halogen;
- R2 is C1-6alkyl or C3-6cycloalkyl, optionally substituted with 1-4 independent halogen;
- R3 is C1-4alkyl, C3-6cycloalkyl, heteroaryl, or phenyl, any of which optionally substituted independently with 1-4 independent halogen or C1-6alkyl;
- R4 is H or C1-4alkyl, said alkyl optionally substituted with 1-4 independent halogen;
- RP is H, halogen, nitrile, or a C1-6alkyl group, said alkyl optionally substituted with 1-4 independent halogen;
- n is 0 or 1;
- and
- when R3 and R4 are connected to each other through X, then R3 and R4 are each C1alkyl, and X is C0-4alkyl.
7 more elements
Dependencies are inferred from the claim text.