Process for the preparation of a collidine and 2,3,5,6-tetramethyl pyridine
AssigneeCouncil of Scientific and Industrial Research
InventorsShivanand Janardan Kulkarni, Kondapuram Vijaya Raghavan, Srinivas Nagabandi, Radha Rani Vippagunta
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Abstract
The present invention provides a process for synthesis of tri- and tetra-alkylated pyridines (i.e. collidines) in high yields by reacting methyl ethyl ketone with formaldehyde in presence of ammonia in gas phase in the presence of a zeolite catalyst which comprises of silica-alumina with atleast one metal ion and/or metal selected from the group consisting of lanthanum, lead, manganese, iron, copper and cobalt. This process provides eco-friendly, more economical and shape-selective heterogeneous method.
Claims10
A process for the preparation of a compound of the formula 1
- 3
- wherein R1 and R3 are H or methyl, R2 and R4 are methyl, the process comprising reacting methyl ethyl ketone or 2-butanol with formaldehyde in presence of ammonia in gas phase and a zeolite ZSM-5 catalyst at a temperature in the range of 350-420° C. and Weight hourly space velocity in the range of 0.25 to 1.00 h−1 to obtain the said compound of formula 1.
A process as claimed in claim wherein R1 is methyl and R3 is H to give 2,3,5-collidine.
A process as claimed in claim wherein R1 is H and R3 is methyl to give 2,3,6-collidine.
A process as claimed in claim wherein R1 and R3 are methyl to give 2,3,5,6-tetramethylcollidine
Dependencies are inferred from the claim text.