Process for the synthesis of an annulated pyridine base
AssigneeCouncil of Scientific and Industrial Research
InventorsShivanand Janardan Kulkarni, Kondapuram Vijaya Raghavan, Radha Rani Vippagunta, Srinivas Nagabandi
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Abstract
This invention relates to process for producing annulated pyridine bases by reacting cyclic ketones with aliphatic aldehyde in presence of ammonia in gaseous phase in the presence of a catalyst. This process provides an eco-friendly, more economical and highly selective heterogeneous method.
Claims14
A process for the synthesis of an annulated pyridine base, said process comprising reacting a cyclic ketone containing 5 to 8 carbon atoms and an aliphatic aldehyde of the formula R1CHO wherein R1 is hydrogen or alkyl having 1 to 3 carbon atoms with ammonia in a gaseous phase, the mole ratio of ammonia to cyclic ketone being in the range of 0.5 to 5.0, the reaction temperature being in the range of 350° C. to 450° C., in the presence of a mesoporous sieve catalyst to obtain said annulated pyridine base.
Dependencies are inferred from the claim text.