Chloropvrimidine intermediates

A process for the preparation of a compound of formula (VI):

• 12
• wherein R3 is hydrogen;
• hydroxyl or a protected hydroxyl;
• a C3-7 carbocyclic group optionally substituted with one or more groups selected from C1-4 alkyl, C1-4 alkoxy, hydroxyl or protected hydroxyl, azido, phosphonyl, or halogen;
• a C2-8 hydrocarbyl group, wherein carbon atoms may be substituted by one or more heteroatoms selected from N, O or S and wherein such C2-8 hydrocarbyl group may be optionally substituted with one or more groups selected from C1-4 alkyl, C1-4 alkoxy, hydroxyl or protected hydroxyl, azido, phosphonyl, or halogen;
• or a C4-7 heterocyclic group, wherein one or more carbon atom is replaced by a N, O, or S atom and wherein such C4-7 heterocyclic group may be optionally substituted with one or more groups selected from C1-4 alkyl, C1-4 alkoxy, hydroxyl or protected hydroxyl, azido, phosphonyl, or halogen;
• provided that such groups are not attached by a glycosidic bond, comprising:
• reacting a compound of formula (III):
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• with an amine of formula R3 NH2 in the presence of a base.