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AssigneeAjinomoto Co., Inc.
InventorsKokichi Kikuchi, Noriyuki Sato, Toshihiko Torigoe, Hiroeki Sahara, Manabu Suzuki, Junji Hamuro
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A tumor antigen gene is identified by screening a cDNA library derived from a gastric cancer cell line that can induce gastric cancer antigen specific cytotoxic T cell (CTL) by means of hybridization and PCR utilizing an amino acid sequence of peptide fragment of a known gastric cancer antigen protein, introducing a selected cDNA clone into a cell of gastric cancer cell line that cannot induce gastric cancer antigen specific CTL so that the clone should be expressed in the cell, and selecting a transgenic cell that has acquired the ability to induce CTL. According to the present invention, there are provided a protein capable of inducing immune response against human gastric cancer, DNA encoding the protein, as well as vaccine for treatment and prevention of human gastric cancer, and agent for treatment and prevention of human gastric cancer.
A DNA which encodes a gastric cancer antigen protein present in a human gastric cancer cell.
A DNA which encodes a peptide containing an amino acid sequence comprising at least amino acids corresponding to amino acid numbers 62-70 of SEQ ID NO:
A gastric cancer antigen protein which comprises an amino acid sequence of SEQ ID NO:
A gastric cancer antigen protein which comprises an amino acid sequence having substitution, deletion, insertion, addition or inversion of one or several amino acids in the sequence of SEQ ID NO:
A peptide which contains an amino acid sequence comprising at least amino acids corresponding to amino acid numbers 62-70 of SEQ ID NO:
Dependencies are inferred from the claim text.