Thermogelling biodegradable aqueous polymer solution
AssigneeBattelle Memorial Institute
InventorsByeong Moon Jeong, Anna Gutowska
Life of this patent
Estimating the term…
Abstract
Disclosed is a thermogelling biodegradable aqueous polymer solution useful in providing a bioactive agent delivery system. The present invention provides a thermogelling biodegradable aqueous polymer solution with a polyethylene glycol (PEG) block and a biodegradable polyester block, where the blocks are linked to form a polymer of a general structure comprising the formula of An(B), where n is greater than 2 and A is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, B is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, and A is different from B.
Claims31
A thermogelling biodegradable aqueous polymer solution, comprising:
- a. a biodegradable polymer, comprising
- i. a polyethylene glycol (PEG) block, and
- ii. a biodegradable polyester block, wherein
- iii. said blocks are linked to form a polymer of a general structure comprising the formula of An(B), where n is greater than 2 and A is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, B is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, and A is different from B;
- and
- b. an aqueous solution.
A biodegradable bioactive agent delivery system, comprising:
- a. an effective amount of bioactive agent contained in;
- b. a thermogelling biodegradable aqueous polymer solution comprising
- i. A biodegradable polymer, comprising a polyethylene glycol (PEG} block a biodegradable polyester block, wherein said blocks are linked to form a polymer of a general structure comprising the formula of An(B), where n is greater than 2 and A is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, B is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, and A is different from B, and
- ii. an aqueous solution.
A method for the parenteral delivery of a bioactive agent in a thermogelling polymer matrix to a warm blooded animal for the controlled release of said bioactive agent, which comprises:
- a. providing an injectable thermogelling biodegradable aqueous polymer solution, which comprises
- i. A biodegradable polymer, comprising a polyethylene glycol (PEG) block, a biodegradable polyester block, wherein said blocks are linked to form a polymer of a general structure comprising the formula of An(B), where n is greater than 2 and A is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, B is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, and A is different than B, and
- ii. an aqueous solution;
- b. mixing said thermogelling biodegradable aqueous polymer solution with an effective amount of bioactive agent to form a polymer-bioactive agent mixture;
- c. maintaining said polymer-bioactive agent mixture at a temperature below the gelling temperature of said polymer;
- and
- d. injecting said solution parenterally into said warm blooded animal forming a gel depot of said bioactive agent and biodegradable polymer as the temperature of the solution is raised by the body temperature of said animal to be above the gelling temperature of said polymer.
A method for the delivery of a bioactive agent in a thermogelling polymer matrix to a warm blooded animal for the controlled release of said bioactive agent, which comprises:
- a. providing a thermogelling biodegradable aqueous polymer solution, which comprises
- i. A biodegradable polymer, comprising a polyethylene glycol (PEG) block, a biodegradable polyester block, wherein said blocks are linked to form a polymer of a general structure comprising the formula of An(B), where n is greater than 2 and A is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, B is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, and A is different than B, and
- ii. an aqueous solution;
- b. mixing said thermogelling biodegradable aqueous polymer solution with an effective amount of bioactive agent to form a polymer-bioactive agent mixture;
- c. maintaining said polymer-bioactive agent mixture at a temperature below the gelling temperature of said polymer;
- and
- d. providing said polymer-bioactive agent mixture into said warm blooded animal forming a gel depot of said bioactive agent and biodegradable polymer as the temperature of the liquid is raised by the body temperature of said animal to be above the gelling temperature of said polymer.
A biodegradable polymer, comprising:
- a. a polyethylene glycol (PEG) block;
- and
- b. a biodegradable polyester block, wherein;
- c. said blocks are linked to form a polymer of a general structure comprising the formula of An(B), where n is greater than 2 and A is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, B is selected from the group consisting of a polyethylene glycol block and a biodegradable polyester block, and A is different from B.
Dependencies are inferred from the claim text.