Back to results
US 2002/0173532 A1Published application
Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
AssigneeHoffmann-La Roche Inc.
InventorsAntonio A. Albano, Wantanee Phuapradit, Harpreet K. Sandhu, Navnit Hargovindas Shah
Life of this patent
Estimating the term…
Abstract
The present invention provides a method of preparing an amorphous, pharmaceutically active form of a compound of formula I 1 which is substantially free of crystalline compound.
Claims2
A method of making a compound of formula I,
- 4
- in amorphous form substantially free of crystalline compound comprising:
- (a) continuously exposing a crystalline compound of formula I to a temperature-controlled extruder (hot melt extruder) that is set at different temperature gradients;
- and
- (b) rapidly cooling the extrudate from step (a).
2 more elements
Dependencies are inferred from the claim text.