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US 2002/0173526 A1Published application
Heterocyclic compounds their production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsAkihiro Tasaka, Takenori Hitaka, Etsuya Matsutani
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Abstract
A compound represented by the formula: 1 wherein m is 1 or 2, R1 is a halogen or an optionally halogenated C1-2 alkyl; one of R2 and R3 is a hydrogen atom and the other is a group represented by the formula: 2 wherein n is 3 or 4; R4 is a C1-4 alkyl group substituted by 1 or 2 hydroxy groups, or a salt thereof shows tyrosine kinase-inhibiting activity.
Claims44
A compound represented by the formula:
- 80
- wherein m is 1 or 2;
- R1 is a halogen atom or an optionally halogenated C1-2 alkyl group;
- one of R2 and R3 is a hydrogen atom and the other is a group represented by the formula:
- 81
- wherein n is 3 or 4;
- R4 is a C1-4 alkyl group substituted by 1 or 2 hydroxy groups, or a salt thereof.
4 more elements
A compound represented by the formula:
- 88
- wherein R1a is fluoro or trifluoromethyl, X1 is a leaving group, and n is 3 or 4, or a salt thereof.
Dependencies are inferred from the claim text.