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US 2002/0173519 A1Published application
Quinoline derivatives
AssigneeActive Biotech AB
InventorsAnders Bjork, Stig Jonsson, Tomas Fex, Gunnar Hedlund
Life of this patent
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Abstract
Compounds of formula (I) 1 and tautomers thereof are effective for the treatment of mammals suffering from diseases resulting from autoimmunity and pathological inflammation.
Claims37
A compound of the formula (I)
- 6
- wherein
- R is selected from the group consisting of ethyl, n-propyl, iso-propyl, n-butyl and allyl;
- R′ is selected from the group consisting of methyl, methoxy, fluoro, chloro, bromo, trifluoromethyl, and OCHxFy,
- wherein
- x=0-2,
- y=1-3 with the proviso that
- x +y =3;
- and with the further proviso that when R′ is methyl R can also be methyl;
- R″ is selected from the group consisting of hydrogen, fluoro and chloro, with the proviso that R″ is fluoro or chloro only when R′ is fluoro or chloro;
- R4 is selected from the group consisting of hydrogen and pharmaceutically acceptable inorganic and organic cations;
- R5 is selected from the group consisting of ethyl, n-propyl, iso-propyl, methoxy, ethoxy, chloro, bromo, trifluoromethyl, OCHxFy, and OCH2CHxFy
- wherein
- x=0−2,
- y=1−3 with the proviso that
- x+y=3;
- R6 is hydrogen;
- or
- R5 and R6 taken together are methylenedioxy;
- and any tautomer thereof.
17 more elements
A method of treating a mammal suffering from pathologic inflammation and autoimmunity comprising administering to said mammal a pharmaceutically effective amount of a compound having the general formula (I)
- 9
- wherein
- R is selected from the group consisting of ethyl, n-propyl, iso-propyl, n-butyl and allyl;
- R′ is selected from the group consisting of methyl, methoxy, fluoro, chloro, bromo, trifluoromethyl, and OCHxFy wherein
- x=0−2,
- y=1−3 with the proviso that
- x+y=3;
- and with the further proviso that when R′ is methyl R can also be methyl;
- R″ is selected from the group consisting of hydrogen, fluoro and chloro, with the proviso that R″ is fluoro or chloro only when R′ is fluoro or chloro;
- R4 is selected from the group consisting of hydrogen and pharmaceutically acceptable inorganic and organic cations;
- R5 is selected from the group consisting of ethyl, n-propyl, iso-propyl, methoxy, ethoxy, chloro, bromo, trifluoromethyl, OCHxFy, and OCH2CHxFy
- wherein
- x=0−2,
- y=1−3 with the proviso that
- x+y=3;
- R6 is hydrogen;
- or
- R5 and R6 taken together are methylenedioxy;
- and any tautomer thereof.
16 more elements
Dependencies are inferred from the claim text.