Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use

A pipenrdine, tetrahydropyridine or piperazine derivative having the formula:

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• any of its enantiomers or any mixture thereof, or an acid addition salt thereof,
• wherein
• B is C1-10-alkylene, C2-10-alkenylene or C2-10-alkynylene;
• X is —O—, —S—, or —CR4R5—;
• and
• Y is —CR6R7—, —CR6R7—CR8R9—, or —CR6—CR7—;
• or
• X and Y together form a group —CR4═CR5—, or —CR4═CR5—CR6R7—;
• Z is —O—, or —S—;
• W is N, C, or CH, and the dotted line is an optional bond;
• R4, R5, R6, R7, R8 and R9 are each independently selected from hydrogen, halogen, trifluoromethyl, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6alkyl, C1-6-alkoxy, C1-6-alkylthio, amino, C1-6-alkylamino, C1-6-dialkylamino, phenylamino or phenyl-C1-6-alkylamino wherein the phenyl group may be substituted, acylamino, hydroxy, —SH, cyano, nitro, —COOR18, —SO2—R19 and C1-6-alkyl substituted with a substituent selected from halogen, C1-6-alkoxy, C1-6alkylthio, amino, C1-6alkylamino, C1-6-dialkylamino, acylamino, hydroxy, —SH, cyano, nitro, —COOR18 and —SO2—R19;
• R18 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, phenyl or phenyl-C1-6-alkyl wherein the phenyl groups may be substituted, amino, C1-6-alkylamino or C1-6-dialkylamino, and
• R19 is C1-6-alkyl, amino, C1-6-alkylamino, C1-6-dialkylamino, phenyl or phenyl-C1-6-alkyl wherein the phenyl groups may be substituted;
• A is a bicyclic ring selected from
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• wherein E1, E2 and E3 are selected from O, S, N, NR11, C, CR12 and CHR13, and the dotted line indicates an optional bond, provided that E2 and E1 and/or E3 may not simultaneously be O, or S;
• R1, R2, R3, R12, R13, R14, R15, R16 and R17 are each independently selected from hydrogen, halogen, trifluoromethy, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkoxy, hydroxy, formyl, acyl, amino, C1-6-alkylamino, C1-6-dialkylamino, acylamino, C1-6-alkoxycarbonylamino, aminocarbonylamino, C1-6-alkylaminocarbonylamino, C1-6-dialkylaminocarbonylamino, nitro, cyano and —SO2-R19, wherein R19 is C1-6-alkyl, amino, C1-6-alkylamino, C1-6-dialkylamino, phenyl, or phenyl-C1-6-alkyl wherein the phenyl groups may be substituted;
• R11 is selected from hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, phenyl or phenyl-C1-6-alkyl wherein the phenyl group may be substituted, acyl, formyl and —SO2—R19, wherein R19 is C1-6-alkyl, amino, C1-6alkylamino, C1-6-dialkylamino, phenyl or phenyl-C1-6-alkyl wherein the phenyl groups may be substituted;
• provided that at least one of R4—R9 is different from hydrogen when A is a group of formula
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