Serotonergic compositions and methods for treatment of mild cognitive impairment
OwnerRichard J. Wurtman, Robert K. K. Leeinventors
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Abstract
A method of treating Mild Cognitive Impairment has been discovered. The treatment method comprises administering an effective amount of a serotonergic agent, including, but not limited to dexnorfenfluramine. The agent can be any serotonergic agonist, partial agonist, serotonin reuptake inhibitor, or combinations of these agents. The treatment method also encompasses combinations of serotonergic agents and non-steroidal anti-inflammatory agents. The treatment method may also delay the onset of Mild Cognitive Impairment, dementia, or both.
Claims16
A method of preventing, delaying, attenuating or ameliorating the symptoms of Mild Cognitive Impairment in a subject comprising:
- administering to the subject an effective amount of an agent that stimulates soluble amyloid precursor protein secretion,
- whereby the impairment is prevented, attenuated or ameliorated.
A method of increasing the level of soluble amyloid precursor protein in the cerebrospinal fluid of a subject comprising:
- administering to the subject an effective amount of an agent that stimulates secretion of soluble amyloid precursor protein into the cerebrospinal fluid, whereby the level of soluble amyloid precursor protein in the cerebrospinal fluid is increased.
A method of decreasing the level of soluble amyloid precursor protein in the cerebrospinal fluid comprising:
- administering an effective amount of a serotonin antagonist.
Dependencies are inferred from the claim text.