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US 2002/0173505 A1Published application
Medicament
OwnerStaffan Skogvallinventor
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OwnerStaffan Skogvallinventor
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A compound having agonist activity to the 5-HT4 receptor for use as a medicament and the use of said compound in the manufacture of a medicament for use in therapeutic or prophylactic treatment of disorders involving bronchocontraction of a human or animal body is described, as well as methods of treatment, wherein said compounds are administered. Further, a compound having antagonist activity to the 5-HT2a receptor for use as a medicament and the use of said compound in the manufacture of a medicament for use in therapeutic or prophylactic treatment or disorders involving bronchocontraction of a human or animal body is described, as well as methods of treatment, wherein said compounds are administered. Moreover, a composition comprising a combination of compounds comprising at least one compound with agonist activity to the 5-HT4 receptor agonist and at least one compound with antagonist activity to the 5-HT2, receptor antagonist is described, as well as such a composition for use as a medicament, the use of said composition for the manufacture of a medicament for therapeutic or prophylactic treatment of disorders involving broncocontraction of a human or animal body, and methods of treatment, wherein said compositions are administered.
Use of one or more compounds having antagonist activity to a 5-HTI. receptor, and derivatives and pharmaceutically acceptable salts thereof having antagonist activity to the 5-HT2. receptor in the manufacture of a medicament for therapeutic or prophylactic treatment of disorders involving human bronchocontraction chosen from the group consisting of asthma and disorders related thereto, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.
Use of one or more compounds having agonist activity to a 5-HT4 receptor in the manufacture of a medicament for therapeutic or prophylactic treatment of disorders involving human bronchocontraction, chosen from the group consisting of asthma and disorders related thereto, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease, wherein said compounds have the capacity of reducing pathological bronchocontraction by at least 30%, preferably at least 60%, and most preferably at least 90%, and wherein said compounds are chosen from the group comprising 5-carboxamidotryptamine, BIMU 1, BIMU 8, BRL 24924, Cisapride, DAU 6236, 5-hydroxy-N,N-dimetyltryptamin, ML-1035, ML 10302, 5-metoxytryptamin, Metoclopramide, Mosapride, 8-OH-DPAT (8-hydroxy-2-dipropylaminotetralin), Prucalopride, R 076186, R 093877, Renzapride, RS 17017, RS 56532, RS 57639, RS 67333, RS 67506, RS 67532, SB 204070, SB 205149, SC-53116, SC-49518, SK-951, SDZ 216-454, SR59768, TKS159, VB20B7, YM-47813, YM-53389, YM-09151, Zacopride, Zelmac, arylcarbamate derivatives of 1-piperidineethanol, 2-piperazinylbenzoxazole derivatives, clebopride, and
Use of a composition comprising a combination of at least one compound with agonist activity to the 5-HT-4 receptor, and at least one compound with antagonist activity to the 5-HT2a receptor for the manufacture of a medicament for therapeutic or prophylactic treatment of disorders involving bronchocontraction, chosen from the group consisting of asthma and disorders related thereto, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease, preferably asthma and disorders related thereto.
Dependencies are inferred from the claim text.