Compositions and methods for the treatment or prevention of inflammation
OwnerMarco Mastradonato, Gianluca Bragutiinventors
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Abstract
The present invention relates to compounds containing as active ingredients hyaluronic acid and polyvinylpyrrolidone, for the treatment of inflammatory, ulcerative and painful conditions of moist epithelial surfaces such as mucositis, stomatitis, vestibulitis, aphthous ulcerations, and Behcet's syndrome.
Claims26
A composition, comprising:
- from about 0.01 to about 5 percent by weight of hyaluronic acid, or a pharmaceutically acceptable salt thereof, having a molecular weight from about 1.6 and 2.2 million daltons;
- from about 0.04 to about 15% by weight of a K60 to K100 polyvinylpyrrolidone, or a pharmaceutically acceptable salt thereof;
- and
- from about 86 to about 98% water,
- wherein the viscosity of the composition is from about 50 to about 500 centipoise.
A composition comprising:
- from about 0.04 to about 5 percent by weight of hyaluronic acid, or a pharmaceutically acceptable salt thereof, with a molecular weight from about 1.6 to about 2.2 million daltons;
- from about 0.08 to about 15% by weight of a K60 to K100 polyvinylpyrrolidone, or a pharmaceutically acceptable salt thereof, and
- from about 86 to about 98% water,
- wherein the viscosity of the composition is from about 50 to about 500 centipoise.
A composition comprising hyaluronic acid or a pharmaceutically acceptable salt thereof;
- glycyrrhetinic acid or a pharmaceutically acceptable salt thereof;
- and polyvinylpyrrolidone or a pharmaceutically acceptable salt thereof.
A method for treating or preventing inflammation in a patient comprising:
- administering to a patient in need thereof an effective amount of a composition comprising:
- (i) from about 0.01 to about 5 percent by weight of hyaluronic acid, or a pharmaceutically acceptable salt thereof, having a molecular weight from about 1.6 to about 2.2 million daltons;
- (ii) from about 0.04 to about 15% by weight of a K60 to K100 polyvinylpyrrolidone, or a pharmaceutically acceptable salt thereof;
- and
- (iii) from about 86 to about 98% water,
- wherein the viscosity of the composition is from about 50 to about 500 centipoise.
A method for treating or preventing inflammation in a patient, comprising administering to a patient in need thereof an effective amount of a composition comprising hyaluronic acid or a pharmaceutically acceptable salt thereof;
- glycyrrhetinic acid or a pharmaceutically acceptable salt thereof;
- and polyvinylpyrrolidone or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.