Chlamydia oligosaccharides
OwnerCho-Chou Kuo, Albertina F. Swanson +2inventors
InventorsCHO-CHOU KUO, ALBERTINA F. SWANSON, SEN-ITIROH HAKOMORI, NORIKO TAKAHASHI
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Abstract
Mannose-containing, branched oligosaccharides mediate binding of chlamydia to mammalian cells. The “high mannose-type” glycan was found to block adhesion of chlamydiae to mammalian cells and thus to inhibit infectivity. The glycan and its mimetics, including multivalent derivatives, can be used as agents for treatment or prevention of chlamydia-based human diseases.
Claims11
A composition comprising a carbohydrate, or a derivative thereof, wherein said carbohydrate comprises at least five mannose residues;
- wherein said carbohydrate comprises a branched trimannosyl core, wherein a mannose residue optionally is bonded thereto;
- wherein said carbohydrate comprises at least three branches and each branch terminates in a mannose residue;
- and wherein said carbohydrate or derivative is present in an amount which inhibits binding of chlamydia to a mammalian cell, and a biologically acceptable carrier, diluent or excipient.
A method of inhibiting binding of chlamydia to a mammalian cell comprising exposing said chlamydia to a carbohydrate, or a derivative thereof, wherein said carbohydrate comprises at least five mannose residues;
- wherein said carbohydrate comprises a branched trimannosyl core, wherein a mannose residue optionally is bonded thereto;
- wherein said carbohydrate comprises at least three branches and each branch terminates in a mannose residue;
- and wherein said carbohydrate or derivative is present in an amount which inhibits binding of chlamydia to a mammalian cell.
An isolated Chlamydia carbohydrate comprising at least five mannose residues;
- wherein said carbohydrate comprises a branched trimannosyl core, wherein a mannose residue optionally is bonded thereto;
- and wherein said carbohydrate comprises at least three branches and each branch terminates in a mannose residue.
A multivalent carbohydrate comprising two or more carbohydrates linked to a carrier, wherein said carbohydrate comprises at least five mannose residues;
- wherein said carbohydrate comprises a branched trimannosyl core, wherein a mannose residue optionally is bonded thereto;
- and wherein said carbohydrate comprises at least three branches and each branch terminates in a mannose residue.
Dependencies are inferred from the claim text.