Methods for the treatment and diagnosis of prostate cancer based on p75NTR tumor supression
OwnerDaniel Djakiewinventor
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Abstract
The present invention provides a method of treatment or prophylaxis of cancer in a subject in need thereof including administering to the subject p75NTR gene or a fragment thereof in an amount effective to increase tumor suppression and/or tumor apoptosis. The p75NTR gene or fragment thereof is administered in an amount sufficient to maintain a level of p75NTR mRNA which at least partially compensates for the loss of p75NTR mRNA associated with p75NTR mRNA degradation in cancerous or precancerous cells. The invention also includes administering to the subject a p75NTR mRNA stabilizing agent (e.g., one or more RNA-binding proteins).
Claims34
A method of treatment or prophylaxis of cancer in a subject in need thereof comprising administering to the subject p75NTR gene or a fragment thereof in an amount effective to increase tumor suppression and/or tumor apoptosis.
A method of treatment or prophylaxis of cancer in a subject in need thereof comprising administering to the subject a p75NTRmRNA stabilizing agent.
A method for early diagnosis of prostate cancer comprising determining p75NTR mRNA levels in prostate tissue of a subject.
A method of reducing or preventing prostate tumor metastasis in a subject in need thereof comprising administering to the subject p75NTR gene or a fragment thereof in an amount effective to prevent or reduce tumor metastasis.
A method of reducing or preventing prostate tumor metastasis in a subject in need thereof comprising administering to the subject a p75NTR mRNA stabilizing agent.
A method for early diagnosis of prostate cancer comprising determining p75NTR expression levels in prostate tissue of a subject.
A method of treatment or prophylaxis of cancer in a subject in need thereof comprising administering to the subject an agent capable of promoting expression of endogenous p75NTR gene in an amount effective to increase tumor suppression and/or tumor apoptosis.
A method of treatment or prophylaxis of cancer in a subject in need thereof comprising administering to the subject p75NTR protein in an amount effective to increase tumor suppression and/or tumor apoptosis.
Dependencies are inferred from the claim text.