Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
AssigneesGeron Corporation, University Technology Corporation
InventorsThomas R. Cech, Joachim Lingner, Toru Nakamura, Karen B. Chapman, Gregg B. Morin, Calvin B. Harley, William H. Andrews
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Abstract
The present invention provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions, including cancer.
Claims18
A method of inhibiting telomerase expression in a cell or growth of a cell, comprising introducing into the cell an isolated antisense oligonucleotide that specifically hybridizes to an hTRT polynucleotide comprising the nucleotide sequence SEQ. ID NO:1.
Dependencies are inferred from the claim text.