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US 2002/0173475 A1Published application
Methods to inhibit viral replication
OwnerAsim Dasgupta, Saumitra Das +1inventors
InventorsAsim Dasgupta, Saumitra Das, Narayan Baidya
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Abstract
Peptides having specific patterns of acidic and aromatic amino acids which inhibit viral infections are described. The peptides contain 15-18 amino acids and may be administered as such, in combination with additional antiviral agents and/or in the form of nucleotide sequences encoding them.
Claims35
A compound of the formula
- A1nA2nA3nA4A5A6A7A8A9A10A11A12A13A14A15A16A17A18 (1)
- and acylated and/or amidated forms thereof,
- wherein each n is independently 0 or 1;
- A1, A2, and A3 are each independently any amino acid;
- A4, A12, and A17 are independently acidic amino acids;
- A13, A14, A15, and A18 are independently aromatic amino acids;
- A5, A7, A8, A11, and A16 represent any amino acid;
- A6, A9, and A10 represent independently a basic amino acid or a polar neutral amino acid;
- wherein each of said amino acids may be in the L form, racemic form, or D form:
6 more elements
Dependencies are inferred from the claim text.