Methods & materials involving dimerization-mediated regulation of biological events
AssigneePresident and Fellows of Harvard College
InventorsStuart L. Schreiber, Gerald R. Crabtree
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Abstract
This invention concerns materials, methods and applications relating to the multimerizing of protein mediators of biological events using synthetic, preferably non-peptidic, dimerizing agents.
Claims7
A method for preparing an agent capable of effecting a biological event mediated by the association of two or more endogenous protein mediator molecules which comprises covalently linking a first compound capable of binding to one of the protein mediators with a second compound capable of binding to the other protein mediator, to form a dimerizing agent capable of binding to both mediator molecules.
Dependencies are inferred from the claim text.