Pharmaceutical formulations of resveratrol
OwnerJohn M. Pezzuto, Richard C. Moon +4inventors
InventorsJohn M. Pezzuto, Richard C. Moon, Mei-Shiang Jang, Aomar Ouali, Shengzhao Lin, Karla Slowing Barillas
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Abstract
A method is provided for preventing or treating skin conditions, disorders or diseases, such as may be associated with or caused by inflammation, sun damage or natural aging. The method involves administration, preferably topical administration, of an active agent selected from the group consisting of resveratrol, pharmacologically acceptable salts, esters, amides, prodrugs and analogs thereof, and combinations of any of the foregoing. Pharmaceutical formulations for use in conjunction with the aforementioned method are provided as well.
Claims65
A method for preventing or treating a skin condition, disorder or disease that is responsive to resveratrol, comprising administering to the susceptible or affected area of the individual's skin a therapeutically effective amount of a topical pharmaceutical formulation that comprises a topical carrier and an active agent selected from the group consisting of resveratrol, pharmacologically acceptable salts, esters, amides, prodrugs and analogs thereof, and combinations of any of the foregoing.
A method for preventing or treating a skin condition, disorder or disease that is responsive to treatment with resveratrol, comprising administering to a susceptible or affected individual a pharmaceutical formulation comprised of a microemulsion containing a therapeutically effective amount of an active agent selected from the group consisting of resveratrol, pharmacologically acceptable salts, esters, amides, prodrugs and analogs thereof, and combinations of any of the foregoing.
A topical pharmaceutical formulation for use in preventing or treating skin conditions, disorders and diseases associated with inflammation, comprising a topical carrier and a therapeutically effective concentration of an active agent selected from the group consisting of resveratrol, pharmacologically acceptable salts, esters, amides, prodrugs and analogs thereof, and combinations of any of the foregoing.
A pharmaceutical formulation comprising:
- approximately 0.25 wt. % to 30 wt. % of an active agent selected from the group consisting of resveratrol, pharmacologically acceptable salts, esters, amides, prodrugs and analogs thereof, and combinations of any of the foregoing;
- approximately 2 wt. % to 20 wt. % emulsifiers;
- approximately 2 wt. % to 20 wt. % emollient;
- approximately 2 wt. % to 50 wt. % solubilizer;
- approximately 0.1 wt. % to 0.2 wt. % preservative;
- and
- water.
Dependencies are inferred from the claim text.