Lipophilic peptides for macromolecule delivery
AssigneeBaylor College of Medicine
InventorsLouis C. Smith, James T. Soarrow, Jochen Hauer, Martha P. Mims
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Abstract
Peptide-macromolecule complexes for delivery of nucleic acid to a cell. The nucleic acid carrier includes a binding complex. The binding complex contains a binding moiety which noncovalently binds to the nucleic acid. The binding complex can also contain a binding moiety which is associated with a surface ligand, nuclear ligand or a lysis agent. These may be associated with the binding moiety by spacers. In addition, the carrier may include a nucleic acid with a combination of the above binding complexes or binding moieties.
Claims29
A peptide-macromolecule complex for delivering a macromolecule into a cell, comprising:
- a non-exchangeable lipophilic peptide comprising a delivery peptide associated with a lipid moiety,
- wherein said delivery peptide portion of said lipophilic peptide is complexed to said macromolecule.
Dependencies are inferred from the claim text.