23927, a novel human ion channel
OwnerRory A. J. Curtis, Inmaculada Silos-Santiagoinventors
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Abstract
The invention provides isolated nucleic acids molecules, designated 23927 or IC23927 nucleic acid molecules, which encode ion channel molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing IC23927 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an IC23927 gene has been introduced or disrupted. The invention still further provides isolated IC23927 proteins, fusion proteins, antigenic peptides and anti-IC23927 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
Claims34
An isolated nucleic acid molecule selected from the group consisting of:
- (a) a nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:1;
- and
- (b) a nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:3.
An isolated nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 2.
An isolated nucleic acid molecule comprising the nucleotide sequence contained in the plasmid deposited with ATCC® as Accession Number ______.
An isolated nucleic acid molecule which encodes a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 2.
An isolated nucleic acid molecule selected from the group consisting of:
- a) a nucleic acid molecule comprising a nucleotide sequence which is at least 90% identical to the nucleotide sequence of SEQ ID NO:1 or 3, or a complement thereof;
- b) a nucleic acid molecule comprising a fragment of at least 2393 nucleotides of a nucleic acid comprising the nucleotide sequence of SEQ ID NO:1 or 3, or a complement thereof;
- c) a nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence at least about 90% identical to the amino acid sequence of SEQ ID NO:2;
- and
- d) a nucleic acid molecule which encodes a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, wherein the fragment comprises at least 100 contiguous amino acid residues of the amino acid sequence of SEQ ID NO:
- 2.
An isolated polypeptide selected from the group consisting of:
- a) a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, wherein the fragment comprises at least 100 contiguous amino acids of SEQ ID NO:
- 2;
- b) a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:2, wherein the polypeptide is encoded by a nucleic acid molecule which hybridizes to a nucleic acid molecule consisting of SEQ ID NO:1 or 3 under stringent conditions;
- c) a polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 90% identical to a nucleic acid comprising the nucleotide sequence of SEQ ID NO:1 or 3;
- d) a polypeptide comprising an amino acid sequence which is at least 90% identical to the amino acid sequence of SEQ ID NO:
- 2.
A method for treating a subject having pain or a pain disorder comprising administering to the subject a IC23927 modulator, thereby treating said subject having a pain disorder.
The method of 29, wherein the IC23927 modulator is capable of modulating IC23927 polypeptide activity.
Dependencies are inferred from the claim text.