Therapeutic intervention to mimic the effect of caloric restriction
OwnerMarco Chaconinventor
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Abstract
Methods are provided for promoting longevity and decreasing the incidence of aging associated pathologies (e.g., cancer) by the administration of one or more of the following LFFA: linoleic, oleic and palmitic acid. Secondary LFFA derived from this set, as well as their CoA derivatives and synthetic analogs, are effective also in promoting longevity and delaying the onset of age associated disorders. In addition, interventions including LFFA and CoA LLFA formulations are described which protect the organism from acute physical stress, tissue damage and hypoxia (either due to trauma or secondary to surgical procedures.
Claims10
A method for improving the health of a mammal comprising administering to the mammal a composition comprising LFFA or analogs thereof, or a composition resulting in endogenous release of LFFA, in an amount sufficient to (a) inhibit thyroid hormone receptor binding in vivo, (b) inhibit Na/K ATPase and Ca ATPase in vivo, (c) conserve energy fuels, (d) reduce oxygen consumption in vivo, (e) cause a decrease in core body temperature in said mammal, and/or (f) activation of protective genes in vivo.
Dependencies are inferred from the claim text.