O-superfamily conotoxin peptides
AssigneesUniversity of Utah Research Foundation, Cognetix, Inc.
InventorsBaldomero M. Olivera, G. Edward Cartier, Maren Watkins, David R. Hillyard, J. Michael McIntosh, Richard T. Layer, Robert M. Jones
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Abstract
The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
Claims38
A substantially pure O-Superfamily conopeptide selected from the peptides set forth in Table 2.
A substantially pure conotoxin peplide selected from the group consisting of the mature toxin peptide sequences disclosed in Table 1 except the peptides Di6.2, Af6.9, KK1, KK2, δ-GmVIA, M6.4, δ-PVIA, δ-PVIA-OH, δ-NgVIA, δ-TxVIA, and Israel TxVIA.
An isolated nucleic acid comprising a nucleic acid coding for an O-Superfamily conotoxin precursor comprising an amino acid sequence selected from the group of amino acid sequences set forth in Table 1.
A substantially pure conotoxin protein precursor comprising an amino acid sequence selected from the group of amino acid sequences set forth in Table 1.
A method of identifying compounds that mimic the therapeutic activity of a O-Superfamily conotoxin, comprising the steps of:
- (a) conducting a biological assay on a test compound to deterimine the therapeutic activity;
- and (b) comparing the results obtained from the biological assay of the test compound to the results obtained from the biological assay of a O-Superfamily conotoxin.
Dependencies are inferred from the claim text.