Method of inducing or enhancing chondrogenesis with extracellular matrix containing gdf-5
AssigneeDepuy Acromed, Inc.
InventorsMOHAMMAD A. HEIDARAN, ROBERT C. SPIRO, ROBIN DAVERMAN, LINSHU LIU
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Abstract
A method and composition are provided for inducing or enhancing chondrogenesis in vivo or in vitro. The method is performed by exposing the cells in vitro or in vivo to an extracellular matrix comprising of type I collagen, type II collagen or a mixture of type I collagen or type II collagen and hyaluronate and further containing GDF-5.
Claims11
A method for inducing or enhancing chondrogenesis in cells comprising the step of exposing said cells to a matrix composition comprising of type I collagen and GDF-5.
A method for inducing or enhancing chondrogenesis in cells comprising the step of exposing said cells to a matrix composition comprising of type II collagen and GDF-5.
A method for inducing or enhancing chondrogenesis in cells comprising the step of exposing said cells to a matrix composition comprising of type I collagen, hyaluronate and GDF-5.
A method for inducing or enhancing chondrogenesis in cells comprising the step of exposing said cells to a matrix composition comprising of type II collagen, hyaluronate and GDF-5.
A composition comprising of an extracellular matrix of type I collagen containing an effective amount of GDF-5 sufficient to induce or enhance chondrogenesis.
A composition comprising of an extracellular matrix of type II collagen containing an effective amount of GDF-5 sufficient to induce or enhance chondrogenesis.
A composition comprising of an extracellular matrix of type I collagen and hyaluronate containing an effective amount of GDF-5 sufficient to induce or enhance chondrogenesis.
A composition comprising of an extracellular matrix of type II collagen and hyaluronate containing an effective amount of GDF-5 sufficient to induce or enhance chondrogenesis.
Dependencies are inferred from the claim text.