US 2002/0173446 A1 · Compounds which bind to the central cavity between HIV-1 gp120 and CD4 and uses thereof

Abstract

This invention provides a method for identifying a compound which inhibits HIV-1 entry into a cell. This invention also provides a compound which inhibits the cavity binding interaction between HIV-1 gp120 and CD4. This invention further provides a method of inhibiting HIV-1 infection of a cell, a method of preventing HIV-1 infection in a subject and a method of treating HIV-1 infection in a subject comprising contacting the cell or administering to the subject an amount of the compound which inhibits the cavity binding interaction between HIV-1 gp120 and CD4 effective to inhibit HIV-1 infection, thereby inhibiting HIV-1 infection of the cell, preventing HIV-1 infection in the subject and treating HIV-1 infection in the subject.

Claims12

Dependent claims

A method for identifying a compound which inhibits HIV-1 entry into a cell:

(a) determining the conformation of a crystal of the central cavity of HIV-1 gp120 in the presence of a ligand;
(b) contacting the crystal of HIV-1 gp120 with the compound;
(c) determining the conformation of the crystalized HIV-1 gp120 central cavity in the presence of the compound;
and
(d) comparing the conformation of the crystalized HIV-1 gp120 central cavity determined in step (c) with the conformation of the crystalized HIV-1 gp120 in step (a) so as to identify a compound which inhibits HIV-1 entry into the cell.

2 more elements

Dependencies are inferred from the claim text.

Compounds which bind to the central cavity between HIV-1 gp120 and CD4 and uses thereof

Life of this patent

Compounds which bind to the central cavity between HIV-1 gp120 and CD4 and uses thereof

Life of this patent

Abstract

Claims12