Loading patent…
OwnerKyle Hammerick, Friedrich B. Prinz +3inventors
InventorsKyle Hammerick, Friedrich B. Prinz, Robert Lane Smith, Ralph S. Greco, Rainer Fasching
Estimating the term…
A device, method and process for three-dimensional spatial localization and functional interconnection of the same or different types of cells. The two or three-dimensional device comprising multiple layers containing wells for cell deposition where both the wells and layers are interconnected through microfluidic channels. A process for fabricating the three-dimensional device and a method for depositing different types of cells within the device in a functional interdependent spatial orientation thereby mimicking physiological functions. The device is useful for diagnostic assays, determination of dysfunction of certain cells in the system, quantification of production of cellular proteins, metabolites, hormones or other cellular products, for organ or tissue replacement, for co-culturing different cells, for testing pharmaceutical agents and as a bioreactor for production of biologicals.
An implantable three-dimensional device or a standalone bioreactor or device for anatomical, histological and spatial inter-reaction of one or several types of cells, cell clusters or tissues, said device comprising:
A method for the functional interaction and regulation of the same or different types of cells within a three-dimensional implantable device or within a stand-alone bioreactor or device, said method comprising steps:
A process for fabricating a three-dimensional device comprises steps of:
An implantable three-dimensional device fabricated from biocompatible or biodegradable material, or a combination of both, said device comprising a multiplicity of containment layers, said layers comprising a multiplicity of wells seeded with cells, cell clusters or tissue, said wells further interconnected vertically, horizontally or inclined through microchannels filled with a medium, buffer, water, blood, serum or other solution, said containment layers enclosed within a support layer comprising an inlet and an outlet, or both.
A three-dimensional bioreactor device for production of cellular products, said bioreactor fabricated from biocompatible or biodegradable material, or a combination of both, said bioreactor device comprising a multiplicity of containment layers, said layer comprising a multiplicity of wells seeded with at lest two different types of cells, cell clusters or tissue, said wells interconnected vertically, horizontally or in incline through microchannels filled with a medium, saline, buffer, water, blood, serum or other solution, said containment layers enclosed within a support layer comprising an inlet and an outlet, or both.
Dependencies are inferred from the claim text.