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US 2002/0173029 A1Published application
Covalent modification of surface protein or carbohydrate
AssigneeAlbany Medical College
InventorMark D. Scott
Life of this patent
Estimating the term…
Abstract
A chemo-physiological structure and method for forming the chemo-physiological structure. In a first embodiment, a cell of an animal is provided. The cell has a membrane surface and a viral receptor coupled to the membrane surface. A linker molecule having a covalently attached polymer is covalently bonded to the membrane surface, the viral receptor, or both. The polymer prevents an extracellular virus from bonding to the viral receptor. In a second embodiment, a linker molecule having a covalently attached polymer is covalently bonded to a capsid of a virus, which prevents the virus from bonding to a viral receptor of an adjacent or nearby animal cell.
Claims125
A chemo-physiological structure, comprising:
- a membrane surface of a cell of an animal;
- a viral receptor coupled to the membrane surface;
- and
- a linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
1 more element
A chemo-physiological structure, comprising:
- a membrane surface of a cell of an animal;
- a viral receptor coupled to the membrane surface;
- and
- a linker molecule covalently bonded to the membrane surface, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
1 more element
A chemo-physiological structure, comprising:
- a membrane surface of a cell of an animal;
- a viral receptor coupled to the membrane surface;
- and
- a linker molecule covalently bonded to the viral receptor, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
1 more element
A chemo-physiological structure, comprising:
- a membrane surface of a cell of an animal, said cell selected from the group consisting of an epithelial cell and an endothelial cell;
- a viral receptor coupled to the membrane surface;
- and
- a linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
1 more element
A chemo-physiological structure, comprising:
- a membrane surface of a nasal epithelial cell of an animal;
- a viral receptor coupled to the membrane surface;
- and
- a linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
1 more element
A chemo-physiological structure, comprising:
- a membrane surface of a pulmonary cell of an animal;
- a viral receptor coupled to the membrane surface;
- and
- a linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
1 more element
A chemo-physiological structure, comprising:
- a membrane surface of a vaginal cell of an animal;
- a viral receptor coupled to the membrane surface;
- and
- a linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
1 more element
A chemo-physiological structure, comprising:
- an animal;
- a membrane surface of a cell within the animal;
- a viral receptor coupled to the membrane surface;
- and
- a linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
2 more elements
A chemo-physiological structure, comprising:
- a human animal;
- a membrane surface of a cell within the human animal;
- a viral receptor coupled to the membrane surface;
- and
- a linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
2 more elements
A chemo-physiological structure, comprising:
- a veterinary animal;
- a membrane surface of a cell within the veterinary animal;
- a viral receptor coupled to the membrane surface;
- and
- a linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
2 more elements
A chemo-physiological structure, comprising:
- a membrane surface of a cell of an animal;
- a viral receptor coupled to the membrane surface;
- and
- a linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer has a long chain length that prevents an extracellular virus from bonding to the viral receptor.
1 more element
A chemo-physiological structure, comprising:
- a membrane surface of a cell of an animal;
- a viral receptor coupled to the membrane surface;
- and
- a linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer inactivates a charge-charge interaction that would otherwise bind an extracellular virus to the viral receptor.
1 more element
A chemo-physiological structure, comprising:
- a membrane surface of a cell of an animal;
- a viral receptor coupled to the membrane surface;
- and
- a linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from entering an interior portion of the cell.
1 more element
A method for forming a chemo-physiological structure, comprising:
- providing a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface;
- and
- covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface;
- and
- covalently bonding a linker molecule bonded to the membrane surface, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface;
- and
- covalently bonding a linker molecule bonded to the viral receptor, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface, said cell selected from the group consisting of an epithelial cell and an endothelial cell;
- and
- covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing a membrane surface of a nasal epithelial cell of an animal and a viral receptor coupled to the membrane surface;
- and
- covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing a membrane surface of a pulmonary cell of an animal and a viral receptor coupled to the membrane surface;
- and
- covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing a membrane surface of a vaginal cell of an animal and a viral receptor coupled to the membrane surface;
- and
- covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing an animal having a cell such that a viral receptor is coupled to a membrane surface of the cell;
- and
- covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing a human animal having a cell such that a viral receptor is coupled to a membrane surface of the cell;
- and
- covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing a veterinary animal having a cell such that a viral receptor is coupled to a membrane surface of the cell;
- and
- covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface;
- and
- covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer has a long chain length that prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface;
- and
- covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer inactivates a charge-charge interaction that would otherwise bind an extracellular virus to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface;
- and
- covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from entering an interior portion of the cell.
A method for forming a chemo-physiological structure, comprising:
- providing an animal having a cell on a membrane surface, said cell having a viral receptor, said cell selected from the group consisting of an epithelial cell and an endothelial cell;
- and
- introducing a linker molecule into the animal, said linker molecule having a polymer covalently attached thereto, wherein said introducing results in the linker molecule being covalently bonded to the membrane surface such that the polymer prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing an animal having a nasal cavity, said nasal cavity having a nasal epithelial cell on an nasal membrane surface, said cell having a viral receptor;
- and
- spraying a linker molecule into the nasal cavity, said linker molecule having a polymer covalently attached thereto, wherein the spraying results in the linker molecule being covalently bonded to the membrane surface such that the polymer prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing a human animal having a lung, said lung having a pulmonary cell on a membrane surface of the lung, said cell having a viral receptor;
- and
- inhaling a linker molecule into the lung, said linker molecule having a polymer covalently attached thereto, wherein the inhaling results in the linker molecule being covalently bonded to the membrane surface such that the polymer prevents an extracellular virus from bonding to the viral receptor.
A method for forming a chemo-physiological structure, comprising:
- providing a human animal having a vagina, said vagina having a vaginal cell on a membrane surface of the vagina said cell having a viral receptor;
- and
- inhaling a linker molecule into the lung, said linker molecule having a polymer covalently attached thereto, wherein the inhaling results in the linker molecule being covalently bonded to the membrane surface such that the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface;
- and
- means for covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface;
- and
- means for covalently bonding a linker molecule bonded to the viral receptor, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface;
- and
- means for covalently bonding a linker molecule to a lysine group at a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface, said cell selected from the group consisting of an epithelial cell and an endothelial cell;
- and
- means for covalently bonding a linker molecule to a lysine group at a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- a membrane surface of a nasal epithelial cell of an animal and a viral receptor coupled to the membrane surface;
- and
- means for covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- a membrane surface of a pulmonary cell of an animal and a viral receptor coupled to the membrane surface;
- and
- means for covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- a membrane surface of a vaginal cell of an animal and a viral receptor coupled to the membrane surface;
- and
- means for covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- an animal having a cell such that a viral receptor is coupled to a membrane surface of the cell;
- and
- means for covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- a human animal having a cell such that a viral receptor is coupled to a membrane surface of the cell;
- and
- means for covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- a veterinary animal having a cell such that a viral receptor is coupled to a membrane surface of the cell;
- and
- means for covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- an animal having a cell such that a viral receptor is coupled to a membrane surface of the cell;
- and
- means for covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer has a long chain length that prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- an animal having a cell such that a viral receptor is coupled to a membrane surface of the cell;
- and
- means for covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer inactivates a charge-charge interaction that would otherwise bind an extracellular virus to the viral receptor.
A chemo-physiological structure, comprising:
- an animal having a cell such that a viral receptor is coupled to a membrane surface of the cell;
- and
- means for covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from entering an interior portion of the cell.
A chemo-physiological structure, comprising:
- an animal having a cell such that a viral receptor is coupled to a membrane surface of the cell, said cell selected from the group consisting of an epithelial cell and an endothelial cell;
- and
- means for covalently bonding a linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer prevents an extracellular virus from entering an interior portion of the cell.
A chemo-physiological structure, comprising:
- an animal having a nasal cavity, said nasal cavity having a nasal epithelial cell on an nasal membrane surface, said cell having a viral receptor;
- and
- means for spraying a linker molecule into the nasal cavity, said linker molecule having a polymer covalently attached thereto, wherein the spraying results in the linker molecule being covalently bonded to the membrane surface such that the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- a human animal having a lung, said lung having a pulmonary cell on a membrane surface, said cell having a viral receptor;
- and
- means for inhaling a linker molecule into the lung, said linker molecule having a polymer covalently attached thereto, wherein the inhaling results in the linker molecule being covalently bonded to the membrane surface such that the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- a human animal having a vagina, said vagina having a vaginal cell on a membrane surface, said cell having a viral receptor;
- and
- means for inhaling a linker molecule into the lung, said linker molecule having a polymer covalently attached thereto, wherein the inhaling results in the linker molecule being covalently bonded to the membrane surface such that the polymer prevents an extracellular virus from bonding to the viral receptor.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid, wherein the virus does not include a Simian Vacuolating Agent virus;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal, and wherein the cell is not a monkey kidney cell.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein the linker molecule includes cyanuric chloride, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein the linker molecule is selected from the group consisting of imidazolyl formate, succinimidyl succinate, succinimidyl glutarate, N-hydroxysuccinimide, 4-Nitrophenol, 2,4,5-trichlorophenol, and a chloroformate, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein the linker molecule does not include cyanuric chloride, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, wherein the polymer includes methoxypolyethylene glycol, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, wherein the polymer wherein the polymer is selected from the group consisting of polyethylene glycol, ethoxypolyethylene glycol, dextran, ficoll, and arabinogalactan, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, wherein the polymer does not include methoxypolyethylene glycol, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid, wherein the virus has human significance;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid, wherein the virus has veterinary significance;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to an amino acid at the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to a lysine group at the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to a carbohydrate at the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to a sulfhydryl group at the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- a cell of an animal;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A chemo-physiological structure, comprising:
- a virus having a capsid;
- a cell of an animal, wherein the cell is not a monkey kidney cell;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A chemo-physiological structure, comprising:
- a virus having a capsid;
- a cell of an animal, wherein the cell is selected from the group consisting of an epithelial cell and an endothelial cell;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A chemo-physiological structure, comprising:
- a virus having a capsid;
- a cell of an animal, wherein the cell is a nasal epithelial cell;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A chemo-physiological structure, comprising:
- a virus having a capsid;
- a cell of an animal, wherein the cell is a pulmonary cell;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A chemo-physiological structure, comprising:
- a virus having a capsid;
- a cell of an animal, wherein the cell is a vaginal cell;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A chemo-physiological structure, comprising:
- a virus having a capsid;
- an animal;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of the animal.
1 more element
A chemo-physiological structure, comprising:
- a virus having a capsid;
- a human animal;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of the animal.
1 more element
A chemo-physiological structure, comprising:
- a virus having a capsid;
- a veterinary animal;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of the animal.
1 more element
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer has a long chain length that causes the polymer to envelop the virus in a manner that prevents the virus from bonding to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer inactivates a charge-charge interaction that would otherwise bind the virus to a cell of an animal.
A chemo-physiological structure, comprising:
- a virus having a capsid;
- and
- a linker molecule covalently bonded to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from entering an interior portion of a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid, wherein the virus does not include a Simian Vacuolating Agent virus;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an anima animal, and wherein the cell is not a monkey kidney cell.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- and
- covalently bonding a linker molecule to the capsid, wherein the linker molecule includes cyanuric chloride, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- and
- covalently bonding a linker molecule to the capsid, wherein the linker molecule is selected from the group consisting of imidazolyl formate, succinimidyl succinate, succinimidyl glutarate, N-hydroxysuccinimide, 4-Nitrophenol, 2,4,5-trichlorophenol, and a chloroformate, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- and
- covalently bonding a linker molecule to the capsid, wherein the linker molecule does not include cyanuric chloride, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, wherein the polymer includes methoxypolyethylene glycol, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, wherein the polymer wherein the polymer is selected from the group consisting of polyethylene glycol, ethoxypolyethylene glycol, dextran, ficoll, and arabinogalactan, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, wherein the polymer does not include methoxypolyethylene glycol, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid, wherein the virus has human significance;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid, wherein the virus has veterinary significance;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- and
- covalently bonding a linker molecule to an amino acid at the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- and
- covalently bonding a linker molecule to a lysine group at the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- and
- covalently bonding a linker molecule to a carbohydrate at the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- and
- covalently bonding a linker molecule to a sulfhydryl group at the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to a cell of an animal.
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- providing a cell of an animal;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- providing a cell of an animal, wherein the cell is not a monkey kidney cell;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- providing a cell of an animal, wherein the cell is selected from the group consisting of an epithelial cell and an endothelial cell;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- providing a cell of an animal, wherein the cell is a nasal epithelial cell;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- providing a cell of an animal, wherein the cell is a pulmonary cell;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- providing a cell of an animal, wherein the cell is a vaginal cell;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- providing an animal;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- providing a human animal;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A method for forming a chemo-physiological structure, comprising:
- providing a virus having a capsid;
- providing a veterinary animal;
- and
- covalently bonding a linker molecule to the capsid, wherein a polymer is covalently attached to the linker molecule, and wherein the polymer envelops the virus in a manner that prevents the virus from bonding to the cell.
1 more element
A chemo-physiological structure, comprising:
- a membrane surface of a cell of an animal;
- a viral receptor coupled to the membrane surface;
- a first linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a first polymer is covalently attached to the linker molecule, and wherein the first polymer prevents an extracellular virus from bonding to the viral receptor;
- the extracellular virus having a capsid;
- and
- a second linker molecule covalently bonded to the capsid, wherein a second polymer is covalently attached to the second linker molecule, and wherein the second polymer envelops the extracellular virus in a manner that prevents the extracellular virus from bonding to the cell of the animal.
3 more elements
A chemo-physiological structure, comprising:
- an animal;
- a membrane surface of a cell within the animal;
- a viral receptor coupled to the membrane surface;
- a first linker molecule covalently bonded to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a first polymer is covalently attached to the linker molecule, and wherein the first polymer prevents an extracellular virus from bonding to the viral receptor;
- the extracellular virus having a capsid;
- and
- a second linker molecule covalently bonded to the capsid, wherein a second polymer is covalently attached to the second linker molecule, wherein the second polymer envelops the extracellular virus in a manner that prevents the extracellular virus from bonding to the cell of the animal, wherein the first linker molecule and the second linker molecule are chemically identical, and wherein the first polymer and the second polymer are chemically identical.
4 more elements
A method for forming a chemo-physiological structure, comprising:
- providing a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface;
- covalently bonding a first linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a first polymer is covalently attached to the linker molecule, and wherein the first polymer prevents an extracellular virus from bonding to the viral receptor;
- providing the extracellular virus having a capsid;
- and
- covalently bonding a second linker molecule to the capsid, wherein a second polymer is covalently attached to the second linker molecule, and wherein the second polymer envelops the extracellular virus in a manner that prevents the extracellular virus from bonding to the cell of the animal.
2 more elements
A method for forming a chemo-physiological structure, comprising:
- providing an animal having a cell such that a viral receptor is coupled to a membrane surface of the cell;
- covalently bonding a first linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a first polymer is covalently attached to the linker molecule, and wherein the first polymer prevents an extracellular virus from bonding to the viral receptor;
- providing the extracellular virus having a capsid;
- and
- covalently bonding a second linker molecule to the capsid, wherein a second polymer is covalently attached to the second linker molecule, wherein the second polymer envelops the extracellular virus in a manner that prevents the extracellular virus from bonding to the cell of the animal, wherein the first linker molecule and the second linker molecule are chemically identical, and wherein the first polymer and the second polymer are chemically identical.
2 more elements
A chemo-physiological structure, comprising:
- providing a membrane surface of a cell of an animal and a viral receptor coupled to the membrane surface;
- means for covalently bonding a first linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a first polymer is covalently attached to the linker molecule, and wherein the first polymer prevents an extracellular virus from bonding to the viral receptor;
- providing the extracellular virus having a capsid;
- and
- means for covalently bonding a second linker molecule to the capsid, wherein a second polymer is covalently attached to the second linker molecule, and wherein the second polymer envelops the extracellular virus in a manner that prevents the extracellular virus from bonding to the cell of the animal.
2 more elements
A chemo-physiological structure, comprising:
- an animal having a cell such that a viral receptor is coupled to a membrane surface of the cell;
- means for covalently bonding a first linker molecule to a tissue member selected from the group consisting of the membrane surface, the viral receptor, and a combination thereof, wherein a first polymer is covalently attached to the linker molecule, and wherein the first polymer prevents an extracellular virus from bonding to the viral receptor;
- the extracellular virus having a capsid;
- and
- means for covalently bonding a second linker molecule to the capsid, wherein a second polymer is covalently attached to the second linker molecule, wherein the second polymer envelops the extracellular virus in a manner that prevents the extracellular virus from bonding to the cell of the animal, wherein the first linker molecule and the second linker molecule are chemically identical, and wherein the first polymer and the second polymer are chemically identical.
2 more elements
Dependencies are inferred from the claim text.