Process for preparation of D-pantothenic acid and/or salts thereof
AssigneeDegussa AG
InventorMechthild Rieping
Life of this patent
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Abstract
D-pantothenic acid and/or a salt thereof or feedstuffs additives comprising these are prepared by fermentation of a microorganism of the Enterobacteriaceae family, in particular one which already produces D-pantothenic acid, wherein the nucleotide sequence(s) in the microorganism which code(s) for the poxB gene is (are) attenuated, in particular eliminated.
Claims25
A process for the preparation of D-pantothenic acid and/or a salt thereof comprising:
- preparing D-pantothenic acid and/or a salt thereof by fermentation of a microorganism of the Enterobacteriaceae family in which at least a nucleotide sequence which codes for a poxB gene is attenuated, thereby attenuating an intracellular activity of pyruvate oxidase.
A microorganism of the Enterobacteriaceae family which produces pantothenic acid and in which the poxB gene is present in attenuated form.
A microorganism of the Enterobacteriaceae family which contains, upstream of the ilGM operon, a ribosome binding site shown in SEQ ID No. 11.
Dependencies are inferred from the claim text.