US 2002/0173007 A1 · Human chemokine polypeptides

Abstract

Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

Claims20

Dependent claims

An isolated polynucleotide comprising a member selected from the group consisting of:

(a) a polynucleotide encoding the polypeptide comprising amino acid—24 to amino acid 72 as set forth in SEQ ID NO:2;
(b) a polynucleotide encoding the polypeptide comprising amino acid 1 to amino acid 72 as set forth in SEQ ID NO:2 (c) a polynucleotide encoding the polypeptide comprising amino acid—23 to amino acid 75 as set forth in SEQ ID NO:4;
(d) a polynucleotide encoding the polypeptide comprising amino acid 1 to amino acid 75 as set forth in SEQ ID NO:4;
(e) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a), (b), (c) or (d);
and
(f) a polynucleotide fragment of the polynucleotide of (a), (b), (c), (d) or (e).

3 more elements

Dependencies are inferred from the claim text.

Human chemokine polypeptides

Life of this patent

Human chemokine polypeptides

Life of this patent

Abstract

Claims20