Sodium channel receptor
OwnerStephane Renard, Francois Besnard +1inventors
InventorsStephane Renard, Francois Besnard, David Graham
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Abstract
hSLNAC1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hSLNAC1 polypeptides and polynucleotides in the design of protocols for the treatment of certain diseases and diagnostic assays for such conditions.
Claims28
An isolated polynucleotide selected from the group consisting of:
- (a) a polynucleotide comprising a nucleotide sequence that has at least 80% identity to a nucleotide sequence encoding the hSLNAC1 polypeptide of SEQ ID NO:
- 2 over its entire length;
- or a nucleotide sequence complementary to said nucleotide sequence,
- (b) a polynucleotide comprising a nucleotide sequence that has at least 80% identity to the cDNA insert deposited at the ATCC with Deposit Number 97987;
- or a nucleotide sequence complementary to said nucleotide sequence.
A DNA or RNA molecule comprising an expression system, wherein said expression system is capable of producing a hSLNAC1 polypeptide comprising an amino acid sequence, which has at least 80% identity with the polypeptide of SEQ ID NO :
- 2 when said expression system is present in a compatible host cell.
A hSLNAC1 polypeptide comprising an amino acid sequence which is at least 80% identical to the amino acid sequence of SEQ ID NO :2 over its entire length.
A hSLNAC1 polypeptide comprising an amino acid sequence which is at least 80% identical to the amino acid sequence encoded by the cDNA contained in ATCC 97987.
An isolated polynycleotide comprising a nucleotide sequence that has at least 80% identity to a nucleotide sequence encoding the polypeptide sequence of SEQ ID NO :
- 4 over its entire length;
- or a nuclotide sequence complementary to said nucleotide sequence.
The polynucleotide sequence of SEQ ID NO:
- 3.
A polypeptide comprising an amino acid sequence which is at least 80% identical to the amino acid sequence of SEQ ID NO:
- 4 over its entire length.
The polypeptide sequence of SEQ ID NO:
- 4.
An isolated polynucleotide comprising a nucleotide sequence that has at least 80% identity to a nucleotide sequence encoding the polypeptide sequence of SEQ ID NO:
- 6 over its entire length;
- or a nucleotide sequence complementary to said nucleotide sequence.
The polynucleotide sequence of SEQ ID NO:
- 5.
A polypeptide comprising an amino acid sequence which is at least 80% identical to the amino acid sequence of SEQ ID NO :
- 6 over its entire lenght.
The polypeptide sequence of SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.