32612, a novel human peptide transporter and uses therefor
AssigneeMillennium Pharmaceuticals, Inc.
InventorsRosana Kapeller-Libermann, Inmaculada Silos-Santiago
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Abstract
The invention provides isolated nucleic acids molecules, designated 32612 nucleic acid molecules, which encode a novel human peptide transporter protein. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32612 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 32612 gene has been introduced or disrupted. The invention still further provides isolated 32612 proteins, fusion proteins, antigenic peptides and anti-32612 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
Claims22
An isolated nucleic acid molecule selected from the group consisting of:
- a) a nucleic acid molecule comprising a nucleotide sequence which is at least 85% identical to the nucleotide sequence of either of SEQ ID NOs:
- 1 and 3
- b) a nucleic acid molecule comprising a fragment of at least 1595 nucleotides of the nucleotide sequence of either of SEQ ID NOs:
- 1 and 3
- c) a nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2;
- d) a nucleic acid molecule which encodes a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, wherein the fragment comprises at least 338 contiguous amino acids of SEQ ID NO:
- 2;
- and
- e) a nucleic acid molecule which encodes a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, wherein the fragment comprises at least 25 contiguous amino acids of SEQ ID NO:
- 2, including at least 5 contiguous amino acids of residues 1-110 of SEQ ID NO:
- 2.
An isolated polypeptide selected from the group consisting of:
- a) a polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 85% identical to a nucleic acid comprising the nucleotide sequence of one of SEQ ID NOs:
- 1 and 3, and a complement of one of these;
- b) a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, wherein the fragment comprises at least 338 contiguous amino acids of SEQ ID NO:
- 2;
- and
- c) a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, wherein the fragment comprises at least 25 contiguous amino acids of SEQ ID NO:
- 2, including at least 5 contiguous amino acids of residues 1-110 of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.