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US 2002/0172983 A1Published application
Diagnosis of pathologies of mononucleated blood cells
OwnerDenis Barritault, Ammar Achour +2inventors
InventorsDenis Barritault, Ammar Achour, Jose Courty, Francoise Baudoin
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Abstract
A process for detecting B lymphocytes including contacting a blood sample from a subject, or a fraction of the blood sample, with HARP polypeptide, a fragment or a derivative thereof, and detecting binding to the surface of B lymphocytes by polypeptide HARP, a fragment or a derivative thereof.
Claims18
A process for detecting B lymphocytes comprising:
- contacting a blood sample from a subject, or a fraction of the blood sample, with HARP polypeptide, a fragment or a derivative thereof;
- and
- detecting binding to the surface of B lymphocytes by polypeptide HARP, a fragment or a derivative thereof.
A process for diagnosing proliferative pathologies of mononucleated cells of blood, comprising:
- detecting B lymphocytes in a target subject's blood sample by contacting the blood sample or a fraction of the blood sample, with HARP polypeptide, a fragment or a derivative thereof;
- detecting binding to the surface of B lymphocytes by polypeptide HARP, a fragment or a derivative thereof;
- measuring the binding rate of HARP on the B lymphocytes;
- and
- comparing the resulting rate to a control value obtained in a healthy subject to associate augmentation of binding of HARP with augmentation in the B lymphocytes and with a proliferative pathology of the mononucleated cells.
2 more elements
Dependencies are inferred from the claim text.