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US 2002/0172977 A1Published application
Covalent modification of abnormal prion protein
AssigneeAlbany Medical College
InventorMark D. Scott
Life of this patent
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Abstract
A prion-physiological structure and associated method of formation. A provided abnormal prion has a transforming power over a normal prion to convert the abnormal prion into defective prion that mimics the abnormal prion. A linker molecule is then bonded to the abnormal prion, wherein a polymer that is covalently attached to the linker molecule facilitates formation of a polymerized abnormal prion that does not have the transforming power over the normal prion.
Claims60
A method for forming a prion-physiological structure, comprising:
- providing an abnormal prion that has a transforming power over a normal prion;
- and
- covalently bonding a linker molecule to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion that does not have the transforming power over the normal prion.
A method for forming a prion-physiological structure, comprising:
- providing an abnormal prion that has a transforming power over a normal prion;
- and
- covalently bonding a linker molecule to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion, and wherein the polymer has a long chain length that inactivates the transforming power.
A method for forming a prion-physiological structure, comprising:
- providing an abnormal prion that has a transforming power over a normal prion;
- and
- covalently bonding a linker molecule to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion, and wherein a camouflaging by the polymer of a charge site at the abnormal prion inactivates the transforming power.
A method for forming a prion-physiological structure, comprising:
- providing an abnormal prion that has a transforming power over a normal prion;
- covalently bonding a linker molecule to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion that does not have the transforming power over the normal prion;
- providing an animal that includes the normal prion;
- and
- introducing the polymerized abnormal prion into the animal.
2 more elements
A method for forming a prion-physiological structure, comprising:
- providing a medium that includes proteinaceous matter, said proteinaceous matter including an abnormal prion or not including the abnormal prion, said abnormal prion having a transforming power over a normal prion;
- providing a linker molecule to which a polymer is covalently attached;
- and
- introducing the linker molecule into the medium such that if the medium includes the abnormal prion then said introducing results in the linker molecule covalently bonding to the abnormal prion to form a polymerized abnormal prion that does not have the transforming power over the normal prion.
1 more element
A method for forming a prion-physiological structure, comprising:
- providing a medium that includes proteinaceous matter, said proteinaceous matter including an abnormal prion or not including the abnormal prion, said abnormal prion having a transforming power over a normal prion;
- providing a linker molecule to which a polymer is covalently attached;
- introducing the linker molecule into the medium such that if the medium includes the abnormal prion then said introducing results in the linker molecule covalently bonding to the abnormal prion to form a polymerized abnormal prion that does not have the transforming power over the normal prion;
- providing an animal that includes the normal prion;
- and
- after introducing the linker molecule, introducing a portion of the medium into the animal.
3 more elements
A prion-physiological structure, comprising:
- an abnormal prion that has a transforming power over a normal prion;
- and
- a linker molecule covalently bonded to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion that does not have the transforming power over the normal prion.
A prion-physiological structure, comprising:
- an abnormal prion that has a transforming power over a normal prion;
- and
- a linker molecule covalently bonded to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion, and wherein the polymer has a long chain length that inactivates the transforming power.
A prion-physiological structure, comprising:
- an abnormal prion that has a transforming power over a normal prion;
- and
- a linker molecule covalently bonded to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion, and wherein a camouflaging by the polymer of a charge site at the abnormal prion inactivates the transforming power.
A prion-physiological structure, comprising:
- an abnormal prion that has a transforming power over a normal prion;
- a linker molecule covalently bonded to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion that does not have the transforming power over the normal prion;
- and
- an animal that includes the normal prion and the polymerized abnormal prion.
1 more element
A prion-physiological structure, comprising a medium having:
- proteinaceous matter that includes an abnormal prion or does not include the abnormal prion, wherein the abnormal prion has a transforming power over a normal prion;
- and
- a linker molecule to which a polymer is covalently attached, wherein if the medium includes the abnormal prion then the linker molecule is covalently bonded to the abnormal prion to form a polymerized abnormal prion that does not have the transforming power over the normal prion.
A prion-physiological structure, comprising an animal that includes a normal prion and a portion of a medium, wherein the medium comprises:
- proteinaceous matter that includes an abnormal prion or does not include the abnormal prion, wherein the abnormal prion has a transforming power over the normal prion;
- and
- a linker molecule to which a polymer is covalently attached, wherein if the medium includes the abnormal prion then the linker molecule is covalently bonded to the abnormal prion to form a polymerized abnormal prion that does not have the transforming power over the normal prion.
A prion-physiological structure, comprising:
- an abnormal prion that has a transforming power over a normal prion;
- and
- means for covalently bonding a linker molecule to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion that does not have the transforming power over the normal prion.
A prion-physiological structure, comprising:
- an abnormal prion that has a transforming power over a normal prion;
- and
- means for covalently bonding a linker molecule to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion, and wherein the polymer has a long chain length that inactivates the transforming power.
A prion-physiological structure, comprising:
- an abnormal prion that has a transforming power over a normal prion;
- and
- means for covalently bonding a linker molecule to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion, and wherein a camouflaging by the polymer of a charge site at the abnormal prion inactivates the transforming power.
A prion-physiological structure, comprising:
- an abnormal prion that has a transforming power over a normal prion;
- means for covalently bonding a linker molecule to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion that does not have the transforming power over the normal prion;
- an animal that includes the normal prion;
- and
- means for introducing the polymerized abnormal prion into the animal.
2 more elements
A prion-physiological structure, comprising:
- a medium that includes proteinaceous matter, said proteinaceous matter including an abnormal prion or not including the abnormal prion, said abnormal prion having a transforming power over a normal prion;
- a linker molecule to which a polymer is covalently attached;
- and
- means for introducing the linker molecule into the medium such that if the medium includes the abnormal prion then said introducing results in the linker molecule covalently bonding to the abnormal prion to form a polymerized abnormal prion that does not have the transforming power over the normal prion.
1 more element
A prion-physiological structure, comprising:
- a medium that includes proteinaceous matter, said proteinaceous matter including an abnormal prion or not including the abnormal prion, said abnormal prion having a transforming power over a normal prion;
- a linker molecule to which a polymer is covalently attached;
- means for introducing the linker molecule into the medium such that if the medium includes the abnormal prion then said introducing results in the linker molecule covalently bonding to the abnormal prion to form a polymerized abnormal prion that does not have the transforming power over the normal prion;
- an animal that includes the normal prion;
- and
- means for introducing a portion of the medium into the animal.
3 more elements
Dependencies are inferred from the claim text.