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AssigneeAGY Therapeutics, Inc.
InventorsMirella Gonzalez-Zulueta, Mehrdad Shamloo, K.C. McFarland, Daniel Chin, Tadeusz Wieloch, Thorsten Melcher
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The present invention identifies a gene whose gene product provides a protective effect against neurological disorders or neuronal injuries. Further, the invention provides methods for diagnosing or assessing an individual's susceptibility to a neuronal injury such as stroke. Also provided are therapeutic methods for treating patients, and methods for prophylactically treating individuals susceptible to various neurological disorders or neuronal injuries. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered or are at risk to suffer such disorders or injuries.
A method for diagnosing occurrence of a stroke or assessing a patient's susceptibility to a stroke, the method comprising detecting in a patient sample an elevated level of UCP-2 expression.
A method for assessing a patient's risk of having a stroke comprising comparing the level of UCP-2 expression in a test sample from the patient with a baseline value, wherein an elevated level of UCP-2 expression in the patient sample relative to the baseline indicates that the patient is at risk for stroke.
The method of claim, 8, wherein the baseline value is an average or mean value for UCP-2 expression in a population of control individuals.
A method for treating a subject having or being susceptible to a neurological disorder or a neuronal injury, the method comprising administering to the subject an effective amount of an agent that increases the activity of UCP-2.
A method for screening for an agent useful for treating a neurological disorder or a neuronal injury, the method comprising identifying an agent that upregulates UCP-2 expression and/or activity.
A method of screening for an agent useful for treating a neurological disorder or a neuronal injury, the method comprising identifying an agent that inhibits cellular apoptosis.
Dependencies are inferred from the claim text.